Speaker at Pharmaceutics and Drug Delivery Systems 2022 - Sadia Javed
Government College University, Pakistan
Title : Hyper-production of cholesterol lowering drug lovastatin using selected Aspergillus niger mutants


Lovastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the conversion of HMG-CoA to mevalonate. Lovastatin is a potent drug to lower down the cholesterol level and prevention of CVD. This study was conducted to improve the Aspergillus terreus GC-81 strain by treating it with N- Ethidium bromide (EB) using acid-treated corn cob as substrate in solid state fermentation for hyperproduction of cholesterol-lowering drug lovastatin. The surface morphology of corncob before and after acid treatment was studied by scanning electron microscope (SEM). High-Performance liquid chromatography (HPLC) was carried out to analyze the concentration of lovastatin. Furthermore, kinetic growth parameters such as u (h-1), Yp/s, Yp/x, Yx/s, qs, Qs, qp also studied to calculate the substrate consumption and product formation for maximum production of lovastatin.


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