Title : Investigation of suitability of hydroxypropyl methylcellulose and pullulan for pressure- assisted microsyringe 3D printing
Abstract:
In response to the escalating demand for personalized medicine tailored to individual genetic variations, a critical need has arisen, particularly in the realm of diseases characterized by genetic diversity, such as cancer. Concurrently, the complexity of managing diseases that necessitate polypharmacy, spanning conditions like cardiovascular diseases, cancer, malaria, and tuberculosis, has underscored the urgency for innovative solutions. In this dynamic landscape, 3D printing technology is emerging as a transformative force in the pharmaceutical domain, facilitating the on-demand production of personalized medicine and custom dosage forms directly at the point of care. At the forefront of this paradigm shift is the exploration of the pressure-assisted microsyringe extrusion (PAM) 3D printing technique. This research delves into the suitability of two key polymers, hydroxypropyl methylcellulose (HPMC) and pullulan, within the context of PAM 3D printing. The investigation extends to the formulation of placebo inks using these polymers, and their subsequent sequential evaluation across a spectrum of parameters. The comprehensive assessment encompasses a multidimensional analysis, including rheological behavior, texture analysis, microscopy, stability, printability, and contact angle. These diverse metrics provide a nuanced understanding of the characteristics and performance of placebo inks. The objective is to identify the most suitable ink for the 3D printing process, considering its rheological properties, structural attributes, stability over time, and overall feasibility for on-demand manufacturing. Among the outcomes of this meticulous evaluation is the identification of a particular ink exhibiting superior printability in comparison to its counterparts. This ink, notably containing Benecel K15M in a concentration of 5% w/w, emerges as a promising platform for the fabrication of single or double-layered planar pharmaceutical dosage forms, with a specific emphasis on films. The significance of this finding lies in its potential to serve as a foundational step toward advancing the capabilities of 3D printing in the pharmaceutical realm. By honing in on a formulation that demonstrates optimal printability, the research lays the groundwork for the development of personalized medicine and tailor-made dosage forms. The emphasis on films as a viable dosage form underscores the versatility and adaptability of 3D printing technology in catering to diverse patient needs. In conclusion, this research not only navigates the intricacies of pressure-assisted microsyringe extrusion (PAM) 3D printing but also contributes valuable insights into the selection of suitable polymers and formulations for the on-demand production of personalized pharmaceuticals. The identified ink, enriched with Benecel K15M, stands poised as a promising avenue for further exploration and integration into the evolving landscape of personalized medicine and advanced pharmaceutical manufacturing technologies.
Audience Take Away Notes:
- Use of pressure-assisted microsyringe extrusion (PAM) 3D printing technique in selection of polymer in pharmaceutical dosage forms
- This will help in selecting the optimum concentration of the polymer in PAM and 3D printing
- This study provides a practical solution in using different polymers for PAM
- This study will be emerged as a play form for the printing of single or double-layered planar dosage forms, especially films
