Title : Synthesis, characterization and antimicrobial evaluation of schiff bases derived from sulfonamides and vanillin
Abstract:
Background and Objective: Sulfonamides are a type of antibiotic that are used to treat several infections caused by microorganisms. Sulfonamides are bacteriostatic, meaning they prevent bacterial growth. This study aimed to produce compounds with better antimicrobial activity.
Methods: By condensation reaction, Schiff bases were synthesized from sulfonamides (sulfamethoxazole, sulfapyridine, sulfathiazole, sulfadiazine and sulfisoxazole) and vanillin to enhance antimicrobial activity of synthesized compounds. The agar dilution method was used to measuring the minimum inhibition concentration (MIC) of synthesized compounds.
Results: The synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR and tested for the antibacterial activity against gram positive bacteria (Staphylococcus aureus), gram negative bacteria (Escherichia coli) and antifungal activity against (Candida albicans). Ciprofloxacin and Fluconazole used as standard drugs for bacteria and fungi.
Conclusion: The Schiff base were synthesized, characterization and displayed greater antibacterial and antifungal activity.
Keywords: Sulfonamide, Schiff base, Synthesis, Vanillin, Antibacterial activity, Antifungal activity.
Audience Take Away Notes:
- The results of this study can be used by the audience, which is mostly composed of drug synthesis and researchers working in the drug design and development, to produce compounds with better antimicrobial activity. By using the knowledge gathered from the study, they can create the several compound and evaluate several biological activity
- The study provides valuable insights into the use of these method for synthesis another chemical compounds. researchers can utilize this information to develop more effective agents, by another method that can prepare the beta lactam compound
- This research can serve as a valuable resource for other faculty members in the field of pharmaceutical chemistry. The study introduces the application of our synthesis compound in different fields, Other faculty members can build upon this research to expand their own investigations, develop new compound, and contribute to the advancement of pharmaceutical chemistry science
- This research provides a practical solution to the problem of sulfonamides because act as bacteriostatic compound. By modify the chemical structure that increase the pharmacological activity. The findings of this study can guide in synthesis compound with better pharmacological activity
- This research study provides new chemical compounds that can assist in the design of other chemical compound. By incorporating this new information, researcher can develop more effective drug
Other benefits:
• Increased the antifungal activity of synthesized compounds
• Change the pharmacological activity of sulfonamides
• Measuring MIC of synthesized compounds
• Contribution to the scientific literature and advancement of pharmaceutical chemistry research
