Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Gus R. Rosania
Keynote Presentation
Gus R. Rosania, University of Michigan College of Pharmacy, United States

Poorly soluble drugs with slow rates of clearance are poised to precipitate in the organism following long term oral administration. In this context, my research group has been characterizing the intracellular crystal-like drug inclusions (CLDIs) that are formed by clofazimine, a [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Esmaiel Jabbari
Keynote Presentation
Esmaiel Jabbari, University of South Carolina, United States

Osteogenesis and vascularization during bone development are coupled by spatiotemporal regulation of paracrine signaling in which the invading vascular endothelial cells secrete osteogenic morphogens to stimulate cell differentiation and bone formation. Conversely, the differenti [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Ulo Langel
Keynote Presentation
Ulo Langel, Stockholm University, Sweden

Recent data on mechanisms and applications of transfection strategies by cell penetrating peptides (CPP) are summarized on the variety of different oligonucleotide cargoes including plasmid, antisense and siRNA oligonucleotides. Introduction of PepFect and NickFect technologies f [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Ernst Wagner
Keynote Presentation
Ernst Wagner, Ludwig-Maximilians-Universitat Munich and Nanosystems Initiative Munich, Germany

Viruses and protein toxins present natural examples for potent intracellular delivery of nucleic acids or proteins. Natural evolution has optimized such carriers that comprise multiple different functions for overcoming the delivery barriers. The evolution process takes advantage [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Teruna J. Siahaan
Keynote Presentation
Teruna J. Siahaan, University of Kansas, United States

One of the major challenges in studying brain function and diseases (i.e., Alzheimer’s, Parkinson’s, multiple sclerosis (MS), and brain tumors) lies in the difficulty in delivering molecules to the brain. The critical obstacle in vivo is the presence of the blood-brai [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Valery A. Petrenko
Oral Presentation
Valery A. Petrenko, Auburn University, United States

Development of precision medicines acting specifically at the site of disease has been a long sought goal for the last century, starting from pioneering works of Paul Ehrlich, who suggested the concept of site-directed chemotherapeutics or ‘magic bullet’. With the dev [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Philippe Barthelemy
Oral Presentation
Philippe Barthelemy, University of Bordeaux, France

The combination of nucleic acids chemistry (e.g., nucleoside, nucleotides, oligonucleotides) with supramolecular principles provides an efficient and powerful approach to prepare well-defined systems with tunable physico-chemical properties and functions. We develop new nano-syst [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Carmen Popescu
Oral Presentation
Carmen Popescu, Roquette America, United States

Fast disintegration formulations like Oral Disintegrating Tablets (ODT) and Oral Disintegration Films (ODF) were emerging in the last decade due to the fact they offer patient convenience and compliance by fast dissolving or disintegrate in the mouth while in contact with the ava [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Giancarlo Morelli
Oral Presentation
Giancarlo Morelli, University of Naples Federico II, Italy

The presentation concerns the obtainment of liposomal doxorubicin in which liposomes are externally modified with a targeting peptide able to drive liposomal doxorubicin in a selective way on membrane receptors over expressed in tumours. We have developed a kit containing a first [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Stephen Hart
Oral Presentation
Stephen Hart, UCL GOS Institute of Child Health, United Kingdom

Cystic Fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), encoding a cyclic AMP-activated chloride channel. CFTR deficiency also regulates the epithelial sodium channel, ENaC, leading to increased sodium and water absorpti [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Fiorenza Rancan
Oral Presentation
Fiorenza Rancan, Charite - Universitatsmedizin Berlin, Germany

Several new therapeutic agents for the treatment of dermatological conditions are emerging. Despite skin accessibility, delivery of drugs across skin and maintenance of a sufficient drug concentration in the target region needs further improvement. Nanocarrier-based approaches ar [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Georgina Kate Such
Oral Presentation
Georgina Kate Such, The University of Melbourne, Australia

The design of ‘smart’ delivery systems with tunable response to their environment is important for developing new therapies, as they allow efficient and controlled therapeutic release to a specific target site. Self-assembled polymeric carriers have generated signific [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Laura Cerchia
Oral Presentation
Laura Cerchia, Istituto per l’Endocrinologia e l’Oncologia Sperimentale “G. Salvatore” (IEOS), Italy

Highly selective compounds emerging for anti-cancer therapy are oligonucleotide aptamers that interact with their targets by recognizing a specific three-dimensional structure. Thanks to their unique properties (small size, high selectivity and sensitivity, high stability, conven [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Hanieh Khalili
Oral Presentation
Hanieh Khalili, University of East London, United Kingdom

Therapeutic proteins (e.g. monoclonal antibodies, cytokines, and enzymes) are widely used in healthcare. Monoclonal antibodies (particularly IgGs) are an important class of protein based-medicine which tend to aggregate and misfold. Therefore, development of stable IgGs remains o [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Arik Dahan
Oral Presentation
Arik Dahan, Ben-Gurion University of the Negev, Israel

Poor aqueous solubility is a major challenge in today’s biopharmaceutics. While solubility-enabling formulations can significantly increase the apparent solubility of the drug, the concomitant effect on the drug’s apparent permeability has been largely overlooked. The [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Ana Margarida Grenha
Oral Presentation
Ana Margarida Grenha, University of Algarve, Portugal

Tuberculosis remains a leading cause of death, although effective therapy is available for many years. Therapeutic failure is mainly due to non-compliance with prolonged treatments, often associated with severe side-effects. New therapeutic strategies are therefore demanded. As t [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Arwyn T. Jones
Keynote Presentation
Arwyn T. Jones, Cardiff University, United Kingdom

Targeting disease processes inside cells with biopharmaceuticals represents a major challenge, not least in overcoming biological barriers such as those posed by the plasma membrane. Investment in this approach is justified when one considers the number individual intracellular t [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Carmen Popescu
Keynote Presentation
Carmen Popescu, Roquette America, United States

In recent years, formulator’s attention was focusing on cyclodextrins as a solubilizing tool for their stubborn APIs (BCS class II and IV)). The reason is obvious: easy to scale up and a successful presence of APIs solubilized with cyclodextrins as both liquid and solid dos [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - El Hassane Larhrib
Keynote Presentation
El Hassane Larhrib, University of Huddersfield, United Kingdom

I will start my presentation by sharing with the audience the importance of particle engineering for different pharmaceutical applications such as oral and inhaled products. In the second part of my talk, I will stress the importance of dry powder inhaler (DPI) devices use and th [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Mino R. Caira
Keynote Presentation
Mino R. Caira , University of Cape Town, South Africa

The physicochemical properties and the performance of both active pharmaceutical ingredients (APIs) as well as new chemical entities (NCEs) can be significantly modified by converting them into different crystalline forms, including polymorphs, solvates, co-crystals and host-gues [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Ricardo Perez Tomas
Keynote Presentation
Ricardo Perez Tomas, University of Barcelona, Spain

Eukaryotic life is compartmentalized and the cells have membranes separating the interior from the outside environment. Similarly, the different organelles inside cells are enclosed by membrane. Correct ion exchange through cellular membranes is an essential process for maintaini [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Andras G. Lacko
Oral Presentation
Andras G. Lacko, University of North Texas Health Science Center, United States

Although lipoprotein-based drug-delivery was proposed as an outstanding platform for diagnostic and therapeutic applications almost 35 years ago, no lipoprotein based formulations have so far reached the clinical trial stage. Due to small size, long residence time in the circulat [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - M. Teresa Carvajal
Oral Presentation
M. Teresa Carvajal, Purdue University West Lafayette, United States

Powder flowability is essential upon handling and during the various unit operations used in the manufacturing of pharmaceutical products. Surface interactions such as cohesive- adhesive contribution depend on the surface composition and particle morphology. The materials used in [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Teresa M. V. D. Pinho e Melo
Oral Presentation
Teresa M. V. D. Pinho e Melo, University of Coimbra, Portugal

The research team has previously reported the synthesis of a new type of stable 4,5,6,7-tetrahydropyrazolo[1,5-a] pyridine-fused chlorins and bacteriochlorins via an [8π+2π] cycloaddition of diazafulveniummethides with porphyrins and chlorins. Absorption spectra of these ch [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Sulabh Patel
Oral Presentation
Sulabh Patel, F. Hoffmann-La Roche Ltd, Switzerland

Following intravitreal (IVT) injection of protein-loaded long acting delivery (LAD) system, therapeutic protein remains in vitreous humor (VH) and gets exposed at physiological pH and temperature for significantly longer duration. Therefore, it is of prime interest to study the s [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Katherina Fernandez
Oral Presentation
Katherina Fernandez, University of Concepcion, Chile

Avoiding wounds in salmon and trout farming systems is an important need of the industry, due their potential production decline effect, caused by decrease of fish meat quality, and the consequent profits loss of the companies. The High frequency of wounds in intensive farming, a [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Rina Rosin-Arbesfeld
Oral Presentation
Rina Rosin-Arbesfeld, Tel-Aviv University, Israel

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in both men and women, with over 1 million people diagnosed each year. In around 85% of the people suffering from a precancerous condition (colorectal adenomas), malignant transformations (carcinomas) or [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Eugenia V Gurevich
Oral Presentation
Eugenia V Gurevich, Vanderbilt University, United States

Arrestins were discovered as the key players in the desensitization of G protein-coupled receptors (GPCRs) by virtue of specific binding to active phosphorylated GPCRs and blocking further G protein activation. Both receptor-bound and free arrestins also initiate multiple signali [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Maria J. Vicent
Oral Presentation
Maria J. Vicent, Polymer Therapeutics Lab, Spain

Polymer conjugates are nanosized hybrids that covalently combine a bioactive agent with a polymer to ensure not only its efficient release to the required intracellular compartment, but also its availability within a specific period of time. Clinical proof of concept for these mu [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Madhav Bhatia
Oral Presentation
Madhav Bhatia, University of Otago, New Zealand

Uncontrolled inflammation is responsible for several diseases, which are major health problems. Hydrogen sulfide (H2 S), a gas with the characteristic odour of rotten eggs, has been recognized as an important endogenous gaseous signalling molecule. Our group is the first in the w [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Luis Braz
Oral Presentation
Luis Braz, University of Algarve, Portugal

During the presentation will be discussed the design of nanoparticles based on locust bean gum (LBG) and chitosan to be used as oral immunoadjuvant for vaccination purposes. The advantages of oral immunization and the importance of LBG for this purpose will be explained. LBG-base [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Sarmad Al-Edresi
Oral Presentation
Sarmad Al-Edresi, University of Manchester, United Kingdom

Resveratrol, a polyphenol, found in grapes and red wine, has been reported to have many potential therapeutic properties. However, resveratrol demonstrates poor water solubility and short biological half-life, and lacks therapeutic efficacy due to inadequate concentration at the [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Arik Dahan
Oral Presentation
Arik Dahan, Ben-Gurion University of the Negev, Israel

I n this lecture, regional-dependent intestinal permeability will be discussed, including dissolution aspects, as well as pathophysiological conditions. Permeability is location dependent, and pertains to each point throughout the gastrointestinal tract. A drug may exhibit signif [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - John Wahlich
Poster Presentation
John Wahlich, John Wahlich (VHsquared Ltd), United Kingdom

Only very few oral peptides have been commercialised to date, these include cyclosporin A (Neoral®) for the treatment of transplantation rejection; desmopressin (DDAVP®) for the treatment of nocturnal enuresis and linaclotide (Linzess®) for the treatment of irritable [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Gemma Vilar
Poster Presentation
Gemma Vilar, Leitat Tecnological Center, Spain

Nanoparticles are an important tool to overcome the administration of drugs, improving the pharmacokinetics of active compounds and avoiding their undesired effects. Specifically, nanoencapsulation offers some advantages such as, protection of the active ingredient from other che [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Anna Kluk
Poster Presentation
Anna Kluk, Zentiva k.s, Czech Republic

Orodispersible films (ODFs) have recently gained much attention as a very beneficial formulation for pediatric and geriatric patients, where the difficulty of swallowing of the standard solid drug forms needs to be eliminated. Orodispersible films either disintegrate quickly in t [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Booyong Lee
Poster Presentation
Booyong Lee, Raphas Co., Ltd, Korea, Democratic People's Republic of

The microneedle-mediated transdermal delivery system has been developed to provide minimal invasive selfadministration method with patient friendly manner. Especially, dissolving microneedles, which deliver the target drugs as the drug-loaded microneedle or medical device to enha [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Mohamad Abadelah
Poster Presentation
Mohamad Abadelah, University of Huddersfield, United Kingdom

Dry powder inhalers (DPIs) have been traditionally developed based on in-vitro testing with a square-wave airflow profile as described in the Pharmacopoeia (USP, 2014). Several studies showed that the Pharmacopoeial flow profile is a poor approximation to reality in some importan [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Tugba Gungor
Poster Presentation
Tugba Gungor, Canakkale Onsekiz Mart University, Turkey

Nitroreductase enzymes catalyze the conversion of the nitro group of prodrug compounds via hydroxylamine to amine group and the active drug inhibits tumor formation by binding to DNA. E. coli NTR/CB1954 (5-aziridinyl-2,4- dinitrobenzamide) is the best known combination that have [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Ana Carolina Kogawa
Poster Presentation
Ana Carolina Kogawa, Univ Estadual Paulista – UNESP, Brazil

Rifaximin is an oral antimicrobial, intestine-selective and non systemic with adverse effects compared to placebo. Rifaximin, until then, does not have standardized analytical methods in most official compendia. Fast, economic, environmentally friendly and selective method indica [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Amal Abukhares
Poster Presentation
Amal Abukhares, University of Manchester, United Kingdom

Introduction: rhIL-1Ra is a recombinant form of the natural anti-inflammatory mediator, interleukin-1 receptor antagonist that competitively binds with type I receptors (IL-1RI). It inhibits effects of other inflammatory mediator, interleukin -1 (IL1). The product is licensed on [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Amit Mirani
Poster Presentation
Amit Mirani, Institute of Chemical Technology, India

The unprotected sexual intercourse associated HIV is one of the most serious challenges to public health all over the world. According to recent reports, sexual transmission is the predominant mode of HIV transmission. This rate could be declined by a prophylactic strategy using [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Ferah Comert Onder
Poster Presentation
Ferah Comert Onder, Canakkale Onsekiz Mart University, Turkey

Triple-negative breast cancer (TNBC) and pancreatic cancers are aggressive malignancies that respond poorly to treatments and is associated with high rates patient deaths despite surgery and adjuvant chemotherapy. With the currently available chemotherapeutics 5-survival rates of [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Pratik S. Kakade
Poster Presentation
Pratik S. Kakade, Institute of Chemical Technology, India

One of the major problems of poorly soluble drugs is low bioavailability. The problem is basically related with BCS class II drugs which are poorly soluble in both aqueous and nonaqueous media. Atovaquone (ATQ), a BCS class II molecule is primarily used to treat or prevent pneumo [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Cansel Kose Ozkan
Poster Presentation
Cansel Kose Ozkan, Gulhane Education and Research Hospital, University of Health Sciences, Turkey

Endomorphin-1 is more effective in the treatment of neuropathic pain than morphine-like analgesics and side effects after treatment are less due to its endogenous nature. However, endomorphin-1 cannot be clinically used for reasons such as short duration of action, poor metabolic [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Gillian Hutcheon
Keynote Presentation
Gillian Hutcheon, Liverpool John Moores University, United Kingdom

The development of new biopharmaceutical therapeutics including proteins, peptides, vaccines, antibodies and nucleic acids is steadily increasing presenting new opportunities for the treatment and prevention of disease. However, it is challenging to effectively deliver these biom [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Mehmet Ay
Keynote Presentation
Mehmet Ay, Canakkale Onsekiz Mart University, Turkey

Conversion of an inactive drug (prodrug) into an active drug is the starting point of the Enzyme Prodrug Therapy (EPT), one of the novel strategies attracted attention increasingly over 20 years to develop new solutions for various illness. Nitroreductases reduce aromatic nitro g [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Ana Carolina Kogawa
Keynote Presentation
Ana Carolina Kogawa, Univ Estadual Paulista – UNESP, Brazil

An adequate analytical method can be the first step in the rational use of pharmaceuticals. Currently, however, the effectiveness of the method of analysis is not enough. It should also be environmentally friendly, dynamic and low cost. A product can present more than one analyti [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Mikhail Samuilovich Goizman
Oral Presentation
Mikhail Samuilovich Goizman, Drugs Technology LLC, Russian Federation

One of the best HIV-protease inhibitors is [(3R,3?S,6?R)-hexahydrofuro[2,3-b]furan-3-ol](1S,2R)-3-[[(4-aminophenyl) sulphonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropyl]carbamate (I) (INN Darunavir). PREZISTA and KEMERUVIR drugs contain Darunavir active pharmaceutical ingredient [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Huan Xie
Oral Presentation
Huan Xie, Texas Southern University, United States

Purpose: GMC1 directly inhibits FKBP52, effectively blocking androgen receptor dependent gene expression and androgenstimulated proliferation. This makes it an attractive option for the treatment of hormone-dependent and hormone-independent prostate cancer. This study investigate [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Omonike A. Olaleye
Oral Presentation
Omonike A. Olaleye, Texas Southern University, United States

Background: Human immunodeficiency virus (HIV) has changed the global profile of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). TB is the leading cause of death in AIDS patients worldwide. The apparent lethal synergy of TB with HIV has made the requir [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Svetlana N. Morozkina
Oral Presentation
Svetlana N. Morozkina, ITMO University, Russian Federation

Steroid estrogens being sex female hormones play crucial role in the functioning of male and female organisms. After menopause, the estrogen level is tragically decreased that causes many disorders like osteoporosis, dementia and cancer development. In this presentation, we will [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Elod Erno Nagy
Oral Presentation
Elod Erno Nagy, University of Medicine and Pharmacy Targu-Mures, Romania

The crosstalk of cartilage and subchondral bone is thought to be a central process in the regulatory pathways of osteoarthritis (OA). Histological changes in OA comprise degeneration and decellularization of the cartilage, elevated bone turnover and subchondral bone attrition. Ou [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Csaba Heteny
Oral Presentation
Csaba Heteny, University of Pecs, Hungary

Optimization of drug-target interactions is a central issue of structure-based drug design. There are fast docking methods available for calculation of the structure and energy of target-ligand complexes. Docking is the computational alternative of experimental structure determin [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Kira Astakhova
Oral Presentation
Kira Astakhova, University of Southern Denmark, Denmark

The main topic that I will discuss is the synthesis of novel peptide-oligonucleotide conjugates (POCs) and evaluation of their therapeutic potential. Our recent data shows that internally labelled POCs (shown in Chart 1) is a promising class of molecules for specific targeting of [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Vandana B. Patravale
Oral Presentation
Vandana B. Patravale, Institute of Chemical Technology, India

Intracellular delivery of anticancer drugs and therapeutic genes (DNA, siRNA, shRNA etc.) is a challenging task faced by pharmaceutical formulators necessitating the need for effective strategies which facilitate superior transfection and endosomal escaping ability. Taking this i [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Jitka Pracharova
Oral Presentation
Jitka Pracharova, Palacky University, Czech Republic

Platinum complexes such as cisplatin [cis-diamminedichloridoplatinum(II)] and its analogues are widely used as very effective chemotherapeutic agents. The anticancer activity of these drugs is related to the hydrolytic release of the labile leaving ligands with concomitant genera [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Elaine F. Enright
Oral Presentation
Elaine F. Enright, University College Cork, Ireland

The symbiotic cohabitation of man and microbe has gained increasing recognition as a determinant of the health status of the human host, affording new insights into disease pathogenesis, as well as novel therapeutic targets. From an oral drug delivery perspective, pharmacokinetic [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Konstantin Ostrovskiy
Oral Presentation
Konstantin Ostrovskiy, Drugs Technology LLC, Russian Federation

Rifapentine is a semisynthetic rifamycin antibiotic highly active against a broad spectrum of microorganisms including Mycobacterium tuberculosis. Rifapentine solubility in water is very low (0.1 mg/ml); therefore, its dosage forms are currently limited to tablets or capsules (e. [....] » Read More

Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2017 - Sandip Gite
Oral Presentation
Sandip Gite, Institute of Chemical Technology, India

Fenofibrate (FNB), a BCS class II molecule is primarily used in hypercholesterolemia and hypertriglyceridemia. FNB presents a poor bioavailability of 36% due to its low solubility. To overcome the issue of solubility related poor efficacy; a nanosuspension based drug delivery sys [....] » Read More

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