Abstract
About this talk
Several new therapeutic agents for the treatment of dermatological conditions are emerging. Despite skin accessibility, delivery of drugs across skin and maintenance of a sufficient drug concentration in the target region needs further improvement. Nanocarrier-based approaches are promising strategies for the further development of dermal and transdermal drug delivery. Different types of nanocarriers possess different physicochemical characteristics and have different penetration and drug release properties upon interaction with skin barriers and cell components. A systematic correlation between nanocarrier physicochemical characteristics and their behavior after topical application is necessary to foster the use of nanotechnology in dermatology. Methods like electron microscopy, atomic force microscopy, stimulated Raman spectroscopy and flow cytometry of single cell suspensions were utilized to determine nanocarriers physicochemical properties and their performance after application on human skin explants. Softness, stability and stimuli-responsiveness have been identified as the most promising characteristics influencing nanocarrier penetration and drug delivery to skin. In particular, soft thermoresponsivenanogels were found to penetrate deeply within the stratum corneum, the outermost skin barrier, changing its permeability and improving drug penetration. Interaction of nanogels with skin antigen presenting cells occurred in both epidermis and dermis. These findings suggest the possibility to develop targeting approaches in order to increase drug delivery to specific cell populations.
Takeaway Notes:
• The importance to correlate chemical composition and physical properties to nanocarrier behavior and delivery performance after topical application on skin will be stressed.
• The talk will illustrate how nanocarriers intrinsic properties can be used to improve skin permeability.
• Methods to monitor the interaction of nanocarriers with skin immune system will be shown.
Speaker
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