The combination of nucleic acids chemistry (e.g., nucleoside, nucleotides, oligonucleotides) with supramolecular principles provides an efficient and powerful approach to prepare well-defined systems with tunable physico-chemical properties and functions. We develop new nano-systems based on nucleic acids chemistry for i) drug delivery applications (therapeutic, theranostic), and ii) tissue engineering. This communication will present novel “smart” nucleic acid derivatives (nucleolipids, Glycosylated-nucleolipidsetc) developed in our lab.
•Lipid based drug delivery systems
•Hydrogels for sustained drug release and regenerative medicine
•Nucleic acid chemistry and biology
Philippe Barthélémy received his doctorate in chemistry from the University of Montpellier II, France in 1993. He was then a postdoctoral fellow at Emory University in the group of Pr Fredric Menger (Lavoisier Grant and Emory Fellowship). In 1995 he was appointed as a temporary lecturer at the University of Avignon and as Associate Professor at the same University in 1996. P. Barthélémy worked also as a Visiting Associate Professor at Duke University in 2001. In 2005 he was appointed as full Professor at the University of Bordeaux Segalen. He is leading the “ChemBioPharm” team of the INSERM U1212. Philippe Barthélémy was Vice President of the University of Bordeaux Segalen (2011-2013). Over the course of his tenure, Barthelemy’s research has yielded more than 110 peer-reviewed publications, more than 15 patents and patent applications, and more than 100 oral invited conferences and oral presentations.