A prodrug is a strategic innovation in biopharmaceutics designed to enhance the absorption, distribution, and delivery of therapeutic agents within the human body. This ingenious approach involves the administration of an inactive precursor that undergoes a biotransformation to the active drug form, either enzymatically or non-enzymatically, after administration.
In biopharmaceutics, prodrugs address challenges such as poor solubility, stability, or limited bioavailability of certain drugs. By converting the active compound into a prodrug, these limitations can be overcome, leading to improved therapeutic outcomes. Prodrugs also allow for targeted drug delivery, minimizing potential side effects and enhancing patient compliance.
The versatility of prodrugs spans various drug classes, including analgesics, antivirals, and anticancer agents. This approach exemplifies the continual evolution of pharmaceutical science in optimizing drug performance and patient well-being. As a key player in the realm of biopharmaceutics, prodrugs pave the way for more efficient and precise drug delivery strategies in the field of medicine.
Title : Development of novel drug delivery pathways enabled by perillyl alcohol (NEO100), A monoterpene with multifaceted biomedical applications
Axel H Schonthal, University of Southern California, United States
Title : From marker to mechanism: Ligand discovery enables functional analysis of OR51E1, an ectopic olfactory receptor, in prostate cancer
Vladlen Slepak, University of Miami, United States
Title : Hepatotoxic botanicals-shadows of pearls
Consolato M Sergi, University of Alberta, Canada
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model based on design-inspired biotech- & biopharma-driven applications to secure the human healthcare and biosafety
Sergey Suchkov, N D Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences & InMedStar, Russian Federation
Title : R&D consultancy at the medicines discovery catapult: De-risking drug discovery for innovators
Adriana Gambardella, Medicine Discovery Catapult, United Kingdom
Title : Biocompatible synthesis of non crystalline iron oxide nanoparticles with stable colloidal properties
Lan Wang, Paretor LLC, United States
Title : Precision diagnostics: Effectiveness of innovative imaging technologies for early detection of lung cancers
Huiqin Yang, ICON Clinical Research Ltd, United Kingdom
Title : Principles and standards for managing healthcare transformation towards personalized, preventive, predictive, participative precision medicine ecosystems
Bernd Blobel, University of Regensburg, Germany
Title : Design and characterization of gum arabic buccal films for protein drug delivery
Krisztian Pamlenyi, University of Szeged, Hungary
Title : Advancing EGFR-targeting macrocyclic peptide-drug conjugates to target KRAS-mutant solid tumors: Design, synthesis, and preclinical evaluations
Akash Panja, Ariel University, Israel