Plasma protein binding is a pharmacokinetic parameter that delineates the association between pharmaceutical agents circulating in the bloodstream and plasma proteins, particularly albumin and globulins. Upon binding to plasma proteins, a drug experiences a reduction in its bioavailability for distribution to various tissues and organs, with only the unbound fraction retaining pharmacological activity. Elevated levels of plasma protein binding are associated with prolonged drug duration, albeit concurrently heightening the potential for drug interactions. Conversely, compounds exhibiting low protein binding typically manifest a shorter half-life and expedited clearance. This phenomenon assumes a critical role in elucidating the therapeutic and toxicological profiles of drugs, alongside facilitating the anticipation of potential interactions with co-administered medications. Various determinants influence plasma protein binding, encompassing drug-specific attributes like molecular dimensions and charge, as well as patient-related factors such as age, gender, and specific medical conditions. Healthcare practitioners are obliged to factor in the nuances of plasma protein binding in medication prescription, as it profoundly shapes dosing strategies and contributes to the interindividual variability in drug responses.
Yong Xiao Wang
Albany Medical College, United States
Consolato M Sergi
Universities of Alberta and Ottawa, Canada
Vladlen Slepak
University of Miami Miller School of Medicine, United States
Andreas M Papas
Antares Health Products, United States
Axel H Schonthal
University of Southern California, United States
Bernd Blobel
University of Regensburg, Germany
Gurpreet Singh
IQVIA, United Kingdom
Rassa Pegahi
UPSA, France
Tanuja Tummala
Harrisburg University of Science and Technology, United States
Natassa Pippa
University of Athens, GreeceSubmit your abstract Today
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