A pharmacophore is a molecular framework that elucidates the essential features required for a ligand to bind to its target receptor with high affinity and specificity. It represents a spatial arrangement of key functional groups critical for biological activity. Pharmacophore modelling plays a pivotal role in drug design and discovery by identifying crucial interactions between ligands and target proteins. This concept aids medicinal chemists in rational drug design, allowing them to optimize molecular structures for enhanced potency and selectivity. Pharmacophore-based virtual screening accelerates the identification of potential drug candidates, streamlining the drug development process. By understanding the essential elements for biological activity, researchers can design molecules with improved pharmacokinetic properties and reduced side effects. In summary, pharmacophores serve as invaluable tools in the quest for novel therapeutic agents, facilitating the creation of more effective and safer drugs.
Yong Xiao Wang
Albany Medical College, United States
Consolato M Sergi
Universities of Alberta and Ottawa, Canada
Vladlen Slepak
University of Miami Miller School of Medicine, United States
Andreas M Papas
Antares Health Products, United States
Bernd Blobel
University of Regensburg, Germany
Huiqin Yang
ICON Clinical Research Ltd, United Kingdom
Srividya Narayanan
Northeastern University, United States
Maria Richards Brown
University College London, United Kingdom
Rassa Pegahi
UPSA, France
Hanieh Khalili
University of East London, United KingdomSubmit your abstract Today
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