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Pharmacometrics In Drug Development

increasingly popular technique for reviewing the results of clinical trials in drug development is pharmacometrics modelling. This chapter focuses on pharmacometrics' theoretical and applied elements. It begins by outlining the fundamental elements of pharmacometrics. The reasoning for the pharmacometrics analysis is then thoroughly reviewed. This includes developing the engineering-based dynamic processes that define the system under consideration, which are obtained by translating biological processes into a mathematical framework; using nonlinear mixed-effect modelling as the statistical modelling approach to define the distribution of the model parameters (pharmacokinetics (PK)/pharmacodynamics (PD)); formulating the model; and using optimization techniques, such as the Monte Carlo expectation maximisation algorithm.

Committee Members
Speaker at Drug Delivery Events - Yong Xiao Wang

Yong Xiao Wang

Albany Medical College, United States
Speaker at Pharmaceutical Conference - Consolato M Sergi

Consolato M Sergi

Universities of Alberta and Ottawa, Canada
Speaker at Drug Delivery Events - Vladlen Slepak

Vladlen Slepak

University of Miami Miller School of Medicine, United States
Speaker at Drug Delivery Events -  Andreas M Papas

Andreas M Papas

Antares Health Products, United States
PDDS 2025 Speakers
Speaker at Pharmaceutical Conference - Axel H Schonthal

Axel H Schonthal

University of Southern California, United States
Speaker at Pharmaceutical Conference - Bernd Blobel

Bernd Blobel

University of Regensburg, Germany
Speaker at Pharma Conferences - Gurpreet Singh

Gurpreet Singh

IQVIA, United Kingdom
Speaker at Pharma Conferences - Rassa Pegahi

Rassa Pegahi

UPSA, France
Speaker at Drug Delivery Events - Tanuja Tummala

Tanuja Tummala

Harrisburg University of Science and Technology, United States
Speaker at Drug Delivery Events - Natassa Pippa

Natassa Pippa

University of Athens, Greece
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