Pharmacokinetics describes what occurs to a drug from the time it enters the body until all traces have left. A medication's pharmacokinetics is divided into four steps. They are digestion, delivery, metabolism, and elimination. The method of administration and how the bodily organs work have an impact on each of these processes. Clinical investigations that help establish the onset, size, and duration of a medication's action must be carried out in order to gather pertinent PK and PD data for a medicine. By creating dose-exposure-response correlations, PK and PD data may be utilised to characterise the safety and effectiveness of a medication. Due to biological diversity, every given medicine may respond differently in various patients. Intrinsic characteristics including age, weight, sex, and genetics are examples of patient-specific factors that affect how medications are digested. The lowest plasma concentration of a medication required to elicit a desirable pharmacological response and the highest plasma concentration of a drug that may be tolerated without unacceptable toxicity are both frequently variable between persons. Because of this, it's critical to develop an ideal dose regimen based on PK and PD data to guarantee that the majority of patients will reach the correct therapeutic exposure range free of unacceptable side effects. This may be done by looking at a drug's PK in relation to its absorption, distribution, metabolism, and excretion processes.
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