Pharmaceutical preformulation is a crucial phase in drug development that focuses on understanding the physical and chemical properties of potential drug candidates before they advance to formulation. This initial stage plays a pivotal role in optimizing drug design, ensuring stability, and predicting how the drug will behave in various dosage forms.
During pharmaceutical preformulation, researchers investigate key parameters such as solubility, stability, and compatibility of the drug with excipients. These studies help in selecting the most suitable form of the drug for further development. Additionally, preformulation studies assess factors like particle size, crystallinity, and polymorphism, influencing the drug's bioavailability and overall efficacy. This proactive approach minimizes the risk of unexpected challenges during later stages of drug development and contributes to the overall success of pharmaceutical formulations.
In essence, pharmaceutical preformulation lays the foundation for informed decision-making, enabling researchers to navigate the complex landscape of drug development with a comprehensive understanding of the physical and chemical attributes of potential therapeutic agents.
- Drug optimization
- Compatibility studies
- Solubility analysis
- Stability analysis
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Title : The impact of metal-decorated polymeric nanodots on proton relaxivity
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil