For patients, taking medication orally is the simplest and most convenient way to do so. It is also typically the safest and least expensive option. The oral medication delivery industry is the largest segment of the entire drug delivery business from a commercial standpoint. The oral route is not without considerable difficulties, though. We start by thinking about the GI tract's structure and physiology, as well as the implications for successful oral medication administration and the considerations that must be made when building effective oral Drug Delivery Systems (DDS). The topic of oral controlled-release (CR) technology is then discussed, starting with the hydrophilic matrix tablet, which is the most popular and effective oral CR technology. There structures that are diffusion- and/or dissolution-controlled. Regional targeting of drugs inside the GI tract is reviewed, including medication targeting to the colon and small intestine (SI) via gastroprotection in the stomach.
Title : Principles and standards for managing healthcare transformation towards personalized, preventive, predictive, participative precision medicine ecosystems
Bernd Blobel, University of Regensburg, Germany
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Vladlen Slepak, University of Miami School of Medicine, United States
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Madhav Bhatia, University of Otago, New Zealand
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Lan Wang, Paretor LLC, United States
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Axel H Schonthal, University of Southern California, United States
Title : A NAMs-compatible mechanopharmacological model of drug penetration in the urinary bladder
Kunal Sharma, Swisss Federal Institute of Technology Lausanne, Switzerland
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Lucas Amaral Machado, University of Sao Paulo State – UNESP, Brazil
Title : Integrated Raman, SERS and computational approaches for the study of bioactive molecules in pharmaceutical chemistry
Maria Cristina Gamberini, University of Modena and Reggio Emilia, Italy
Title : The impact of metal-decorated polymeric nanodots on proton relaxivity
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil
Title : Hepatotoxic botanicals-shadows of pearls
Consolato M Sergi, University of Alberta, Canada