For patients, taking medication orally is the simplest and most convenient way to do so. It is also typically the safest and least expensive option. The oral medication delivery industry is the largest segment of the entire drug delivery business from a commercial standpoint. The oral route is not without considerable difficulties, though. We start by thinking about the GI tract's structure and physiology, as well as the implications for successful oral medication administration and the considerations that must be made when building effective oral Drug Delivery Systems (DDS). The topic of oral controlled-release (CR) technology is then discussed, starting with the hydrophilic matrix tablet, which is the most popular and effective oral CR technology. There structures that are diffusion- and/or dissolution-controlled. Regional targeting of drugs inside the GI tract is reviewed, including medication targeting to the colon and small intestine (SI) via gastroprotection in the stomach.
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Axel H Schonthal, University of Southern California, United States
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Vladlen Slepak, University of Miami School of Medicine, United States
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Consolato M Sergi, University of Alberta, Canada
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model based on design-inspired biotech- & biopharma-driven applications to secure the human healthcare and biosafety
Sergey Suchkov, N D Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences & InMedStar, Russian Federation
Title : R&D consultancy at the medicines discovery catapult: De-risking drug discovery for innovators
Adriana Gambardella, Medicine Discovery Catapult, United Kingdom
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Lan Wang, Paretor LLC, United States
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Huiqin Yang, ICON Clinical Research Ltd, United Kingdom
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Bernd Blobel, University of Regensburg, Germany
Title : Design and characterization of gum arabic buccal films for protein drug delivery
Krisztian Pamlenyi, University of Szeged, Hungary
Title : Advancing EGFR-targeting macrocyclic peptide-drug conjugates to target KRAS-mutant solid tumors: Design, synthesis, and preclinical evaluations
Akash Panja, Ariel University, Israel