Opthalamic Drug Delivery Systems
Ophthalmic drug delivery systems encompass a range of specialized methods and technologies designed for the targeted administration of medications to the eyes. These systems play a crucial role in treating various ocular conditions by enhancing drug efficacy, improving patient compliance, and minimizing side effects.
Intraocular Injections:
Intravitreal Injections: Direct injections into the vitreous cavity of the eye, commonly used for treating conditions such as macular degeneration or diabetic retinopathy. Implantable Devices:
- Ocular Inserts: Solid devices placed in the conjunctival sac that release drugs gradually over an extended period, providing a sustained therapeutic effect.
- Drug-Eluting Contact Lenses: Contact lenses designed with materials that release drugs onto the ocular surface for controlled and prolonged drug delivery.
Challenges and Innovations:
- Tear Turnover: Addressing the dynamic nature of tear turnover is a challenge for ensuring prolonged drug retention in the eye.
- Corneal Barrier: Overcoming the corneal barrier is a focus for developing strategies that facilitate effective drug penetration into intraocular tissues.
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