Drug Interactions refer to modifications in a drug's effects brought on by recent or contemporaneous use of another drug or medicines (drug-drug interactions), ingesting food (drug-nutrient interactions), or ingesting dietary supplements (dietary supplement-drug interactions). A drug-drug interaction may make one or both medications work more or less effectively. Clinically relevant interactions are typically unintended and frequently predicted. Therapeutic failure or negative consequences might happen. Rarely can a practitioner employ known drug-drug interactions to achieve a desired treatment outcome. For instance, co-administration of lopinavir with ritonavir to HIV-infected individuals causes changes in lopinavir metabolism and enhances serum lopinavir concentrations and efficacy. When two medications with comparable qualities are taken together, the effects are cumulative. When two medications with comparable qualities are taken together, the effects are cumulative. For instance, using a benzodiazepine for anxiety and a different one before night for sleeplessness may have a cumulative impact and cause poisoning.
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