"CNS Drug Delivery" involves the precise delivery of medications to the Central Nervous System (CNS), comprising the brain and spinal cord. This specialized discipline concentrates on devising methods and technologies to augment the conveyance of therapeutic substances through the blood-brain barrier. The objective is to ensure the accurate and effective treatment of neurological disorders and diseases. Strategies encompass advancements in nanotechnology, specialized drug formulations, and targeted delivery systems, all tailored to surmount the distinct challenges associated with reaching the CNS. These innovations aim to enhance the efficacy of treatments for conditions like neurodegenerative diseases, epilepsy, and psychiatric disorders. Delivering drugs to the CNS poses unique challenges due to the blood-brain barrier (BBB), a protective barrier that restricts the passage of many substances from the bloodstream into the brain. Overcoming this barrier is essential for effectively treating neurological disorders and conditions. Here are some key aspects of CNS drug delivery:
- Blood-Brain Barrier (BBB): The BBB limits the entry of drugs into the brain, protecting it from potential toxins. It impedes the effective transport of therapeutic substances. Overcoming or bypassing the BBB is a significant focus in CNS drug delivery research.
- The Blood-Cerebrospinal Fluid Barrier (BCSFB): Regulates the exchange between blood and cerebrospinal fluid, influencing drug transport in the central nervous system (CNS). Understanding and addressing BCSFB dynamics are crucial in developing strategies for effective drug delivery to treat neurological conditions while navigating the complexities of CNS barriers.
- The Brain-Interstitial Fluid Barrier: Regulates substance transport within brain tissue, influencing drug distribution. Overcoming this barrier is crucial in Central Nervous System (CNS) drug delivery. Innovative formulations and delivery methods are explored to enhance drug penetration and efficacy for improved treatment of neurological disorders.
Consolato M Sergi
Universities of Alberta and Ottawa, Canada
Vladlen Slepak
University of Miami Miller School of Medicine, United States
Andreas M Papas
Antares Health Products, United States
Sergey Suchkov
The Russian University of Medicine and Russian Academy of Natural Science-Moscow, Russian FederationSubmit your abstract Today
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