Title: Prototyping and evaluating a novel humanoid chewing robot for drug delivery using a medicated chewing gum

Kazem Alemzadeh

University of Bristol, UK


Kazem Alemzadeh has completed his PhD from the University of Bradford, United Kingdom. He is a senior lecturer in the Department of Mechanical Engineering at the University of Bristol and he is being part of the Clinical Trails Unit at the Bristol School of Oral and Dental Sciences. He has carried a wide research and has numerous scientific publications and has been serving as an editorial board member.


The global pharmaceutical industry is worth $300 billion dollars per annum and a nearly third is spent on drug delivery. It is estimated it could be worth nearly $1.6 trillion by 2020. Medicated chewing gum is a new developing drug delivery method, with a promising future. Its potential has not yet been fully exploited because current in-vitro dissolution apparatus/chewing machine cannot simulate the human chewing action and forces accurately to influence drug release rate because of the complexities involved in mastication. And also most of these devices do not have the ability to combine mastication, saliva and chewing gum similar to human and subsequently measuring the dissolution/release of compounds from chewing gums.
     The aim of this study is to validate the use of the newly developed humanoid chewing simulator to extract xylitol in-vivo and in-vitro from commercially available chewing gum and quantify its release over time.
Audience take away:
• Why the current in-vitro apparatus/chewing machine used for medicated chewing gum cannot simulate the human chewing action?
• Why the mastication of two devices chosen by Ph.Eur.8, Apparatus (A and B) are not similar to real mastication?
• What is bionic engineering design and how could it help?