Title : Polydopamine based advance drug delivery systems
Abstract:
Polydopamine (PDA) has attracted significant interest as a multifunctional material for advanced drug delivery systems due to its bioinspired catechol amine chemistry, excellent biocompatibility, and strong surface adhesion. The rich chemical functionality of PDA enables versatile non-covalent interactions, including hydrogen bonding, π–π stacking, and coordination interactions, allowing efficient drug loading and controlled release behaviour. In this work, PDA-based delivery platforms were developed to encapsulate therapeutic agents for biomedical applications, with a focus on improving drug stability, sustained release, and localised therapeutic efficacy. Physicochemical characterisation confirmed successful drug incorporation and nanoscale stability of the PDA systems. In vitro release studies demonstrated controlled and stimulus-responsive release profiles, highlighting the tunability of PDA based carriers. The results demonstrate that PDA based advanced drug delivery systems provide a flexible and robust platform for the delivery of antimicrobial and antioxidant agents, offering promising potential for wound healing and other therapeutic applications. This study highlights the role of PDA as a versatile material in the design of next generation drug delivery architectures within supramolecular and bio interface chemistry.
