Janice Mani, Central Queensland University, Australia
Numerous commercial pharmaceuticals – including anticancer, antiviral, and antidiabetic drugs have been developed from traditional plant-derived medicines. With approximately 25,000 species of flora occurring in Australia that are adapted to the harsh environment, there is [....]
» Read More
Crystallization is a widely used purification and a unit operation in pharma and chemical industries. Ibuprofen will be used as a model API in this presentation which is an analgesic. However commercial ibuprofen particles are irregular shape and size with rough surfaces. And sho [....]
» Read More
Introduction and aim: Topical application delivers active compounds directly to the site of affliction on the skin, circumventing first-pass metabolism that occurs with oral delivery. In this study, the in vitro diffusion parameters of various compounds in liquid, gel and cream f [....]
» Read More
Ciprofloxacin HCL is a second generation fluoroqinolone antibiotic, the most commonly used for the treatment of various infectious diseases like urinary tract infections against a wide range of Gram-positive and Gram-negative bacteria. However, many studies revealed that ciproflo [....]
» Read More
Thiazolidinediones form drugs that treat insulin resistance in type 2 diabetes mellitus. Troglitazone represents the first drug from this family, which was removed from use by the FDA due to its hepatotoxicity. As an alternative, rosiglitazone was developed, but it was under the [....]
» Read More
More than 60 percentage of new drugs synthesized suffered from poor water solubility limitation. Water poor solubility consequently leads poor oral bioavailability in many new molecules. Selection of appropriate formulation for such drugs is creating a lot many challenges to the [....]
» Read More
Nanotherapeutics is a rapidly progressing area in the field of Nanomedicine, which is being utilized to overcome several limitations of conventional drug, including poor aqueous solubility, lack of site-specific targeting, rapid systemic clearance, intestinal metabolism and syste [....]
» Read More
Obesity is a chronic inflammatory disease that represents a risk factor for number of diseases including diabetes, steatohepatitis, and cancer. Using safe natural compounds to ameliorate obesity and its related metabolic syndrome is an interesting spot for research. We investigat [....]
» Read More
Mansureh Ghavamm, University of Kashan, Iran (Islamic Republic of)
Green tea is made from the unfermented leaves of Camellia sinensis (L.) Kuntze and is grown in Asia and parts of Africa. This plant is in the form of shrub or tree and has evergreen leaves that reach a height of 2 to 10 meters. Black tea brew is one of the most popular drinks in [....]
» Read More
Crystallization of pharmaceutical ingredients, primarily those that possess several polymorphic forms, particle size and morphology critical properties, are among the most serious and least understood manufacturing procedure. Many processes and product failures can be traced to a [....]
» Read More
The research and development of various nanotechnology platforms have received notable attention in the field of drug delivery, including diagnostics and therapy. However, there are numerous hurdles hindering their clinical translation and one, among them, is related to instabili [....]
» Read More
Zoltan Banoczi, Institute of Chemistry, Eotvos Lorand University, Hungary
Cell-penetrating peptides may be useful tools in drug delivery, however they have some limitations. These limitations; low stability, endosomatic internalisation and thus the vesicular entrapment reduce their applicability. Thus there is high effort to improve their biochemical p [....]
» Read More
Abhishek Gupta, University of Wolverhampton, Walsall Campus., United Kingdom
Wound healing is a complex physiological process and can fail to progress through the timely sequence of healing stages due to many underlying factors, including the invasion of various bacterial and fungal pathogens. Despite an improved understanding of the wound healing process [....]
» Read More
Toxic substances and secretions of animals such as snakes, spiders and scorpions have been used in traditional medicine for the treatment of several diseases. Despite of the inherent difficulty and high economic risk in the discovery and development of new drugs from natural prod [....]
» Read More
Introduction: Inflammatory eye diseases are one of the most common diseases in contemporary societies. Polyphenolic additives in artificial tears have antioxidative, antibacterial and anti-inflammatory properties, which are important in seeking a positive treatment effect. Poplar [....]
» Read More
Florin Borcan, University of Medicine and Pharmacy, Romania
Genetic and cellular therapies represent a group of new techniques based on overlapping fields of biomedical research with similar goals. A new approach in this domain is represented by the development of different personalized gene therapies for patients with rare diseases. &nbs [....]
» Read More
Title : In vitro anticancer screening of crude plant polar extracts
Janice Mani, Central Queensland University, Australia
Numerous commercial pharmaceuticals – including anticancer, antiviral, and antidiabetic drugs have been developed from traditional plant-derived medicines. With approximately 25,000 species of flora occurring in Australia that are adapted to the harsh environment, there is [....] » Read More
Title : Crystallization Process of API ( Active Pharmaceutical Ingredients) for Dosage form Design
Md Abdur Rashid, King Khalid University, Saudi Arabia
Crystallization is a widely used purification and a unit operation in pharma and chemical industries. Ibuprofen will be used as a model API in this presentation which is an analgesic. However commercial ibuprofen particles are irregular shape and size with rough surfaces. And sho [....] » Read More
Title : In vitro pharmacokinetics of topically applied compounds from various formulations across porcine skin
Armorel Diane van Eyk, University of the Witwatersrand, South Africa
Introduction and aim: Topical application delivers active compounds directly to the site of affliction on the skin, circumventing first-pass metabolism that occurs with oral delivery. In this study, the in vitro diffusion parameters of various compounds in liquid, gel and cream f [....] » Read More
Title : Experimental design of ciprofloxacin HCl-loaded nanoparticle formulation for an enhanced antimicrobial activity
Ozge Esim, Ankara University, Turkey
Ciprofloxacin HCL is a second generation fluoroqinolone antibiotic, the most commonly used for the treatment of various infectious diseases like urinary tract infections against a wide range of Gram-positive and Gram-negative bacteria. However, many studies revealed that ciproflo [....] » Read More
Title : Mechanistic Insights into Side Effects of Troglitazone and Rosiglitazone Using a Novel Inverse Molecular Docking Approach
Katarina Kores, University of Maribor, Slovenia
Thiazolidinediones form drugs that treat insulin resistance in type 2 diabetes mellitus. Troglitazone represents the first drug from this family, which was removed from use by the FDA due to its hepatotoxicity. As an alternative, rosiglitazone was developed, but it was under the [....] » Read More
Title : Boosting Oral Bioavailability Though Solid Lipid Nanoparticle Approach
Bhupendra Gopalbhai Prajapati, Ganpat University, India
More than 60 percentage of new drugs synthesized suffered from poor water solubility limitation. Water poor solubility consequently leads poor oral bioavailability in many new molecules. Selection of appropriate formulation for such drugs is creating a lot many challenges to the [....] » Read More
Title : Design and formulation of doxycycline polymeric nanoparticles and testing antitumor and antiangiogenic activity in mouse colon cancer model
Sawsan Zaitone, Suez Canal University, Egypt
Nanotherapeutics is a rapidly progressing area in the field of Nanomedicine, which is being utilized to overcome several limitations of conventional drug, including poor aqueous solubility, lack of site-specific targeting, rapid systemic clearance, intestinal metabolism and syste [....] » Read More
Title : Amelioration effect of black seed oil against high-fat diet-induced obesity in rats through Nrf2/HO-1 pathway
Nada F. Abo El-Magd, Mansoura University, Egypt
Obesity is a chronic inflammatory disease that represents a risk factor for number of diseases including diabetes, steatohepatitis, and cancer. Using safe natural compounds to ameliorate obesity and its related metabolic syndrome is an interesting spot for research. We investigat [....] » Read More
Title : Application of Camellia sinensis (L.) Kuntze in traditional medicine and virus control
Mansureh Ghavamm, University of Kashan, Iran (Islamic Republic of)
Green tea is made from the unfermented leaves of Camellia sinensis (L.) Kuntze and is grown in Asia and parts of Africa. This plant is in the form of shrub or tree and has evergreen leaves that reach a height of 2 to 10 meters. Black tea brew is one of the most popular drinks in [....] » Read More
Title : Strategy in crystallization process to ensure solid state stability of drug substance
Marino Nebuloni, Parma University, Italy
Crystallization of pharmaceutical ingredients, primarily those that possess several polymorphic forms, particle size and morphology critical properties, are among the most serious and least understood manufacturing procedure. Many processes and product failures can be traced to a [....] » Read More
Title : Drying techniques to stabilize nanotechnology
Francesca Selmin, Università degli Studi di Milano, Italy
The research and development of various nanotechnology platforms have received notable attention in the field of drug delivery, including diagnostics and therapy. However, there are numerous hurdles hindering their clinical translation and one, among them, is related to instabili [....] » Read More
Title : Modification of peptides to increase their cellular uptake
Zoltan Banoczi, Institute of Chemistry, Eotvos Lorand University, Hungary
Cell-penetrating peptides may be useful tools in drug delivery, however they have some limitations. These limitations; low stability, endosomatic internalisation and thus the vesicular entrapment reduce their applicability. Thus there is high effort to improve their biochemical p [....] » Read More
Title : Synthesis and characterization of biosynthetic cellulose based hydrogels with the potential wound dressing applications to tackle chronic wounds
Abhishek Gupta, University of Wolverhampton, Walsall Campus., United Kingdom
Wound healing is a complex physiological process and can fail to progress through the timely sequence of healing stages due to many underlying factors, including the invasion of various bacterial and fungal pathogens. Despite an improved understanding of the wound healing process [....] » Read More
Title : Snake and scorpion venom as a source for drugs to treat cancer and central nervous system diseases
Leo K Iwai, Instituto Butantan, Brazil
Toxic substances and secretions of animals such as snakes, spiders and scorpions have been used in traditional medicine for the treatment of several diseases. Despite of the inherent difficulty and high economic risk in the discovery and development of new drugs from natural prod [....] » Read More
Title : Ophthalmic in situ gels with balsam poplar buds extract: formulation, rheological characterisation and quality evaluation
Monika Stanciauskaite, Lithuanian University of Health Sciences, Lithuania
Introduction: Inflammatory eye diseases are one of the most common diseases in contemporary societies. Polyphenolic additives in artificial tears have antioxidative, antibacterial and anti-inflammatory properties, which are important in seeking a positive treatment effect. Poplar [....] » Read More
Title : Affinity effects on the release of genetic material from polyether-urethane particles
Florin Borcan, University of Medicine and Pharmacy, Romania
Genetic and cellular therapies represent a group of new techniques based on overlapping fields of biomedical research with similar goals. A new approach in this domain is represented by the development of different personalized gene therapies for patients with rare diseases. &nbs [....] » Read More