Title : γ-Cyclodextrin metal–organic frameworks as an advanced platform for high-efficiency drug delivery and controlled release
Abstract:
Advanced drug delivery systems are designed to address key limitations of conventional formulations, particularly poor solubility, limited bioavailability, and lack of controlled release. γ-Cyclodextrin-based metal organic frameworks (γ-CD-MOFs) have recently emerged as promising carriers, combining the biocompatibility of γ-cyclodextrin with the high porosity and tuneable architecture of MOFs.
This poster presents a focused overview of γ-CD-MOFs as versatile platforms for drug delivery, highlighting their synthesis, activation, and drug encapsulation capabilities. Particular emphasis is placed on how structural features—such as pore size, surface area, and crystallinity—influence drug loading efficiency and release behaviour. The host–guest inclusion properties of γ-cyclodextrin, integrated within a porous framework, enable high loading of poorly water-soluble drugs and support sustained and controlled release profiles. Importantly, this architecture confers a dual encapsulation capability, enabling the incorporation of both hydrophobic and hydrophilic drugs through complementary host–guest interactions and accessible framework cavities. Key advantages of γ-CD-MOFs include enhanced drug stability, improved dissolution, and the potential for functionalization to enable targeted delivery. These features position γ-CD-MOFs as strong candidates within advanced drug delivery systems. The poster also outlines current challenges, including stability under physiological conditions, scalability of synthesis, and considerations for pharmaceutical translation. Overall, γ-CD-MOFs represent an emerging and adaptable platform with significant potential to advance the design of next-generation drug delivery systems.
