Title : Stimuli-responsive smart drug delivery systems: Emerging strategies in precision medicine
Abstract:
The recent developments in the pharmaceutical field have shown major drawbacks regarding the traditional drug delivery system such as the lack of bioavailability, non-specific distribution, and dose-related systemic toxicity. Stimuli-responsive smart drug delivery systems (SDDS) have become a promising approach to precision medicine to overcome these difficulties. These smart delivery vehicles are made to discharge therapeutic agents following certain internal signals including pH, enzymes, and redox environments, or outside stimuli including temperature, light, and magnetic fields. The use of different types of smart drug carriers such as polymeric nanoparticles, liposomes, hydrogel, micelles and dendrimers have displayed improved targeting of the drug, controlled drug release and improved treatment effects. In addition, nanotechnology and pharmaceutics have enhanced stability of drugs, bioavailability, and specific site delivery, thus, SDDS is specifically applicable in treatment of cancer, neurological diseases, and chronic inflammatory diseases. Although they have potential, they still face a number of obstacles like complexity in formulation, large-scale production, biocompatibility, and regulatory approval, which still restrict their clinical translation. This poster demonstrates about new trends in stimuli-responsive smart drug delivery systems, their working principles, pharmaceutical uses, benefits, and challenges linked with it. In general, smart drug delivery systems are an innovative product in the contemporary method of delivering drugs, providing new opportunities of targeted and personalized therapeutic interventions.
Keywords: Smart drug delivery system; Stimuli-reactive system; Nanotechnology; Precision medicine; Targeted therapy.
