Abstract
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Azobenzene derivatives have the potential to enable light-induced modulation of biological activity. In this study, azobenzene-enriched PEG-PLGA micelles were developed as a delivery system for a selected anticancer agent, with the aim of improving its delivery properties and enabling biological evaluation.
The active compound was successfully encapsulated into PEG-PLGA micelles, yielding a stable micellar system. The developed system was characterized in terms of particle size using dynamic light scattering. Its biological activity was evaluated in MDA-MB-231 triple-negative breast cancer cells with and without light exposure to assess the effect of light on the antiproliferative response. These findings highlight the potential of this new type of PEG-PLGA micelles as a delivery platform for anticancer agents and support further investigation of light-related biological effects in personalized medicine applications.
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