Shripriya Kalbhavi, Lynbrook High School, United States
Despite the widespread use of hypodermic needles in intradermal medication delivery, they remain a source of pain and trauma in patients young and old. The research introduces a novel approach to active medication delivery using microneedle arrays, utilizing the high swellability [....] » Read More
Title : Nanomaterial-mediated systemically administered m-RNA-based gene therapy directed exclusively to cancer, present successes and future prospects
A C Matin, Stanford University, United States
The presentation focuses on systemically administered targeted gene therapy using mRNA instead of DNA; why the former is superior for this purpose will be discussed. Lipid nanoparticles (LNPs) and, more recently, extracellular vesicles (EVs, aka exosomes) have proven effective ve [....] » Read More
Title : Personalized and precision medicine (PPM) as a unique healthcare model to be set up via biodesign, bio- and chemical engineering, translational applications, and upgraded business modeling to secure the human healthcare and biosafety
Sergey Suchkov, The Russian University of Medicine and Russian Academy of Natural Science-Moscow, Russian Federation
Traditionally a disease has been defined by its clinical presentation and observable characteristics, not by the underlying molecular mechanisms, pathways and systems biology-related processes specific to a particular patient (ignoring persons-at-risk). A new systems approach to [....] » Read More
Title : Preparation and characterization of fibers crafted from PCL/PVP-ChAgG, coupled with investigating their suitability as wound dressings.
Luis Jesus Villarreal Gomez, FCITEC - Universidad Autónoma de Baja California, Mexico
Wound dressings play a pivotal role in wound care by cleansing, shielding, and covering wounds, thereby influencing healing duration, cost-effectiveness, and patient comfort. Electrospun fibers emerge as a promising avenue in this field due to their diverse attributes, including [....] » Read More
Title : Is your drug delivery formulation harming the environment ? Approaches to both save human health and the environment
Thomas J. Webster, School of Health Sciences and Biomedical Engineering and Mansfield Bioincubator, China
Today’s biomaterials are harming the environment and left unchanged, are predicted to continue to harm the environment in the decades ahead at an alarming rate. Whether through a large carbon footprint during manufacturing, catheter waste, or extensive polymeric cell cultur [....] » Read More
Title : Clinical pharmacology of aprocitentan (an endothelin receptor antagonist) – The most recent quality progress in treatment of resistant hypertension
Miroslav Radenkovic, University of Belgrade, Serbia
Hypertension is a common condition characterized by persistently high blood pressure (140/90 mmHg or higher). Lowering high blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. Regardless of outstanding result [....] » Read More
Title : Clinical decision making in advanced and metastatic breast cancer cases between PARP inhibitors and CDK4/6 inhibitors
Priya Hays, Hays Documentation Specialists, LLC, United States
Background: PARP inhibitors and CDK 4/6 inhibitors have been studied extensively as model targeted agents for advanced and metastatic breast cancer with hormone receptor positive/HER2 negative molecular subtype, the most common in the patient population. Both agents have been eva [....] » Read More
Title : Emerging formulation and delivery applications of vitamin E TPGS
Andreas M Papas, Antares Health Products, United States
Vitamin E TPGS (d-α-tocopheryl polyethylene glycol 1000 succinate) combines the functions of solubilizer, emulsifier, and absorption enhancer of lipophilic and poorly soluble drugs. In addition, it enhances drug bioavailability and efficacy through inhibition of the P-glyco [....] » Read More
Title : Novel nano drug platform for pharmacologically inducing therapeutic hypothermia (TH) after traumatic brain injury (TBI)
Jorge David Tovar Castro, University of Miami Miller School of Medicine, United States
Therapeutic hypothermia (TH) has gained widespread recognition as a neuroprotective strategy for mitigating secondary injury mechanisms resulting from traumatic brain injury (TBI). TBI occurs when an external force impacts the skull, causing damage to the brain. TH modulates neur [....] » Read More
Title : Global drug development - Trends, challenges and opportunities
Gurpreet Singh, IQVIA, United Kingdom
The entire process of developing a drug from preclinical research to marketing can take approximately 12 to 18 years and often costs well over $1 billion. Global Top Pharmaceutical Companies based on projected R&D spending in 2026 are Roche, Johnson & Johnson, Merck [....] » Read More
Title : Drug design for the development of long-acting injectables
Thomas Ullrich, Novartis Biomedical Research, Switzerland
Long-acting injectable (LAI) medications represent the combination of a powerful drug substance and an injectable drug formulation that guarantees that the affected tissue is consistently exposed to the active molecule for an extended therapeutic treatment period without elicitin [....] » Read More
Title : Synthesis and properties of new unique heterocyclic systems: Pyrido[3'',2'':4',5']furo(thieno)[3',2':4,5]pyrimido[2,1-f][1,2,4]triazines
Anush, National Academy of Sciences of the Republic of Armenia, Armenia
Furo(thieno)[2,3-b]pyridines are “privileged medicinal scaffolds”, used for the development of pharmaceutical agents, showing a wide range of pharmacological activities. Their annulated derivatives attracted big interest of the scientific community due to their broad [....] » Read More
Title : Development and evaluation of prolonged-release dutasteride transdermal delivery system
Shereen M. Assaf, Jordan University of Science and Technology, Jordan
Benign prostatic hyperplasia (BPH), an enlargement of the prostate affecting older men, leads to urinary complications. Oral administration of Dutasteride (DTS) is a common treatment, but it poses challenges for the elderly, including difficulty in taking the medication by mouth, [....] » Read More
Title : Design and assessment of transdermal delivery system containing Levodopa-Loaded Nanoparticles
Shereen M. Assaf, Jordan University of Science and Technology, Jordan
Levodopa, an essential precursor of dopamine, was widely used to address motor disorders in the early stages of Parkinson's disease. However, its effectiveness was hindered by a short plasma half-life, enzymatic conversion in the systemic circulation, limited absorption in th [....] » Read More
Title : Kisspeptin-10 signaling: Unveiling pathways in cervical cancer
Deisy Yurley Rodriguez Sarmiento, Universidad Autonoma de Bucaramanga, Colombia
This presentation will show into the intricate cellular signaling mechanisms mediated by kisspeptin-10 (KP10) in cervical cancer cells, focusing specifically on its interaction with the Kiss1R receptor. The role of KP10 in modulating various G protein-coupled receptor (GPCR) path [....] » Read More
Title : Understanding medical education
Rehan Haider, Riggs Pharmaceuticals, Pakistan
Understanding medical education involves a comprehensive grasp of the multifaceted processes that prepare individuals for medical practice. It encompasses various domains, including curriculum design, teaching methodologies, assessment strategies, and the broader socio-cultural c [....] » Read More
Title : Detection of SARS-CoV-2 RNA in conjunctival secretions of hospitalized patients with confirmed coronavirus disease 2019
Ghazala Rubi, Lahore General Hospital, Pakistan
Background: Coronavirus disease-2019 (Covid-19) caused by novel Corona Virus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), spreads primarily through close contact with respiratory droplets. This novel coronavirus has also been linked to ocular manifest [....] » Read More
Title : Therapeutic and toxic effects of enantia chlorantha (Annonaceae) stem bark extracts in salmonella typhi-induced rats
Djimeli Namekong Merline, Dschang University, Cameroon
Bacteria are responsible for a large number of diseases worrying the world today. Medicinal plants have always been used by poor communities of the African continent as an alternative for the treatment of those diseases. Typhoid fever is one of those diseases caused by salmonella [....] » Read More
Title : PEO Hydrophilic tablet matrix systems as controlled release oral dosage forms using different water soluble drugs and antioxidants
Saeed Shojaee, Medway School of Pharmacy, Iran (Islamic Republic of)
Hydrophilic matrix systems are currently some of the most widely used drug delivery systems for controlled release oral dosage forms. Among a variety of polymers, polyethylene oxide (PEO) is one of the most important materials used in pharmaceutical formulations. As PEO is sensit [....] » Read More
Title : The development of ternary and quaternary solid dispersion-based hydrotropic blends of atorvastatin calcium
Suren Azad Ramadhan, Knowledge University, Iraq
Objective: The major goal of this current experimental study was to use various hydrotropic agents in the formation of solid dispersion-based hydrotropic blends to improve the solubility properties of poor aqueous soluble drug atorvastatin calcium (ATV). Since, atorvastatin calci [....] » Read More
Title : Synthesis, characterization and antimicrobial evaluation of schiff bases derived from sulfonamides and vanillin
Sarhang Hayyas Mohammed, Knowledge University, Iraq
Background and Objective: Sulfonamides are a type of antibiotic that are used to treat several infections caused by microorganisms. Sulfonamides are bacteriostatic, meaning they prevent bacterial growth. This study aimed to produce compounds with better antimicrobial activity. M [....] » Read More
Title : Supercritical microfluidic system for production of nanoparticles and liposomes for pharmaceutical formulation
Yusuke Shimoyama, Tokyo Institute of Technology, Japan
Pharmaceutical formulation techniques have been developed as achieving controlled-release system and high bioavailability of active pharmaceutical ingredients (APIs). Formation of the pharmaceutical suspension with nanoparticles or liposomes is one of the dosage forms to increase [....] » Read More
Title : The role of cellulose nanofibers on co-encapsulation of probiotics and mesalazine in colon-specific microparticles for the treatment of ulcerative colitis: Encapsulation efficiency, morphology, and probiotic viability
Andreia Bagliotti Meneguin, Sao Paulo State University, UNESP, Brazil
Ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD) affecting the colon and rectum, has an unknown etiology. Key symptoms include reduced pH, accelerated colonic transit, diarrhea, and imbalance in intestinal microbiota (dysbiosis). Probiotics (PBTs), when survivi [....] » Read More
Title : Liposomes containing moxifloxacin and functionalized with a siderophore analog for tuberculosis treatment
Fernando Rogerio Pavan, Sao Paulo State University, UNESP, Brazil
Tuberculosis (TB) is an infectious disease that affects millions of people annually and resistance to available antibiotics has worsened this scenario. Another particularity of Mycobacterium tuberculosis, the main etiologic agent of TB, is its ability to survive inside of macroph [....] » Read More
Title : An updated review on the central mechanism of action of paracetamol (Acetaminophen): Experimental evidence and potential clinical impact
Rassa Pegahi, UPSA, France
Paracetamol remains the recommended first-line option for mild-to-moderate acute pain in general population and particularly in vulnerable populations. Despite its wide use, debate exists regarding the analgesic mechanism of action (MoA) of paracetamol. A growing body of evidence [....] » Read More
Title : Lipid media with supercritical CO2 for promoted formation of itraconazole cocrystals
Yuna Tatsumi, Tokyo Institute of Technology, Japan
Pharmaceutical cocrystal is one of the crystal engineering techniques to improve the solubility and bioavailability of active pharmaceutical ingredients (APIs). Cocrystal is a crystal composed of API and other molecules called as coformer. There are many fabrication techniques fo [....] » Read More
Title : Analysis for the optimal angle and injection position in retrodiscal approach transforaminal epidural steroid injection (RA-TFESI)
Pyung Bok Lee, Seoul National University, Korea, Republic of
Background: Transforaminal Epidural Steroid injection(TFESI) is known to be an effective treatment for pain caused by lumbar diseases such as intervertebral disc herniation , spinal stenosis. This study aims to find out the optimal angle of needle insertion at the time of re [....] » Read More
Title : Nanoemulsion drug delivery system of hypericin as antidepressant-like effects
Ahmad Abdullah Salawi, Jazan University, Saudi Arabia
The current project was designed to prepare an oil-in-water (oil/water) hypericin nanoemulsion using eucalyptus oil for the preparation of an oil phase with chitosan as an emulsion stabilizer. The study might be a novelty in the field of pharmaceutical sciences, especially in the [....] » Read More
Title : Polymeric-based formulation for intelligent drug delivery
Mutaz S. Salem, Jordan University of Science and Technology, Jordan
Conventional oral formulations are mainly absorbed in the small intestine. This limits their use in the treatment of some diseases associated with the colon, where the drug has to act topically at the inflammation site. This paved the way for the development of a smart colonic dr [....] » Read More
Title : Formulation, optimization and in vitro characterization of microcapsules of Cymbopogan martini essential oil
Christina Haile Shoddo, Armauer Hansen Research Institute, Ethiopia
Complex coacervation is one of the microencapsulation techniques by which encapsulated substances release profile improved. This study was conducted by using complex coacervation to formulate and optimize microcapsules of the Cymbopogan martini essential oil. Preliminary st [....] » Read More
Title : Strategies for self-medication practice amongst selected households in Ethiopian rural areas
Seifu Hailu Ambissa, Yanet Health and Business College, Ethiopia
This study investigated prevalence and determinants of self-medication practice, with the intention to develop a strategy to reduce irresponsible self-medication practice among rural households in Gimbichu district, Ethiopia. The study was quantitative, descriptive cross-sectiona [....] » Read More
Title : Deep drug discovery of mac domain of SARS-CoV-2 (WT) spike inhibitors: Utilizing experimental ACE2 inhibition TR-FRET assay screening and molecular dynamic simulations and free energy calculations
Saleem iqbal, CHU Research Center and Laval University, Canada
SARS-CoV-2 exploits the homotrimer transmembrane Spike glycoproteins (S protein) during host cell invasion. Omicron, delta, and prototype SARS-CoV-2 receptor-binding domain show similar binding strength to hACE2 (Angiotensin-Converting Enzyme 2). Here we utilized multi-ligand vir [....] » Read More