Speaker at Pharma Virtual 2020 2020 - Rohit Bhatia
ISF College of Pharmacy, India
Title : Coumarin-dihydropyrimidinone hybrids: design, virtual screening, synthesis and cytotoxic activity against breast cancer


Breast cancer is the most invasive form of cancer in women. It is characterized by over production of oestrogens which is mainly  mediated  by  over-expression  of  aromatase.  In  the  presented  work  we  have  designed  a  library  of  fifty  coumarindihydropyrimidinone hybrids and screened them virtually for their aromatase inhibitory potentials through molecular docking tools. Docking was carried out against human aromatase (PDB Id: 3S7S) using exemestane as standard drug. Six compounds with best docking scores and interactions were selected and also analysed for in silico drug likeliness and toxicity. Further these six compounds were synthesized and characterized through spectrometric techniques. Further these were evaluated for cytotoxic potentials against breast cancer cell lines using MTT assay. Compounds CD8 and CD28 were found most potent among the all. The synthesized compounds must be explored further for discovery of a suitable therapeutic candidate against breast cancer.


Dr. Rohit Bhatia is currently working as Assistant Professor in Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga; India.  He  has  pursued  his  PhD  from  MRSPTU,  Bathinda;  India.  He  has  a  total  of  6  years  of  research  experience.  His  area  of  expertise  is computer aided drug design, medicinal chemistry and bio-analysis. He has more than 40 publications in reputed International and National Journals. He has won several awards in National and International awards.