Title : Anti-diabetic and Hypolipdimic potential of Musa paradisiaca L. superfluous material in diabetic rats
Diabetes is severe chronic metabolic disease characterized by high blood glucose levels leads to generation of reactive oxygen species that causes oxidative damage in kidney, liver and pancreas.The aim and purpose of present research work was to find out the antidiabetic and hypolipdimic potential of commonly available and economical medicinal plant i.e Musa paradisiaca L bract and tracheal fluid methanolic extract. For this purpose, diabetes was induced in rats with alloxon, two standard drugs (Glibenclamide 2.5 mg/kg orally, insulin 4 U/200 mg/dl blood sugar subcutaneous injection) and different doses (100 mg/kg, 250 mg/kg and 500 mg/kg) of morphological parts (bract, and tracheal fluid) methanolic extract were administered orally to different groups for 20 days to the diabetic rats. Fasting blood glucose level and weight of rat was measures every fifth day and TG, TC, HDL-C, LDL-C, VLDL, TC/HDL and LDL/HDL was find out at the end of experiment. Histopathology of pancreas was performed. Results of fasting blood glucose level, change in weight, TG, TC, HDL-C, LDL-C, VLDL, TC/HDL and LDL/HDL was analyzed by using ANOVA followed by turkey test, compared with positive and negative control and graph was drawn by using the 5th version of graph pad prism. It is concluded from the results that tracheal fluid has significant antidiabetic and hypo-lipidimic activity whereas bract have non-significant activity.