Impact of sugars on electrospray-dried peptide/protein powder formulations

Title : Impact of sugars on electrospray-dried peptide/protein powder formulations

Abstract:

Electrospray drying is an emerging technique gaining attention in the pharmaceutical industry, particularly for the formulation of biologics and nanoparticles. It enables the production of particles with controlled morphology and size through rapid solvent evaporation driven by an applied electrostatic field. Unlike conventional drying methods that rely on high temperatures, electrospray drying preserves the structural integrity of heat-sensitive peptides and proteins, making it well-suited for inhalable drug delivery systems. A recent study investigated the influence of electric fields and sugar-based excipients on protein stability during electrospray drying. The findings highlight the potential to optimize processing parameters and excipient selection to enhance the performance of protein-based formulations. This presentation highlights the potential of optimizing electrospray parameters to enhance peptide and protein delivery by achieving optimal particle morphology, particularly for drug delivery applications such as inhalable formulations.

Biography:

M. Teresa Carvajal is a Faculty Member at the Agricultural and Biological Engineering at Purdue University. She worked in the pharmaceutical industry, Roche, Bayer and Transave for a total of 14 years prior to joining Purdue. She graduated with a MS in Physical Pharmacy, from the University of Arizona, USA and with a PhD in Powder Pharmaceutical Technology at the University of Bath, UK. Tere’s research group on material sciences focuses on microstructure, surface/interface interactions and energetics, and their impact on powder performance properties such as flowability, aerosolization, entrainment, during formulation, processing and manufacturing. She has authored or co-authored more than 70 peer reviewed articles.