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Title: Dissolution study of drug release from biopolymer matrix tablets

Kevin Matzick

University of Pardubice, Czech Republic

Biography

My name is Kevin Matzick and I was born in Czech Republic. I am PhD student (first year) of University of Pardubice, Faculty of Chemical Technology, Department of Physical Chemistry. My specialization is kinetics of drug release (in vitro), especially preparation of matrix tablets, dissolution tests ant their mathematical evaluation. I also use other analytical techniques like FT-IR spectroscopy or UV/VIS spectroscopy. I‘m also able to work with various software like OriginLab, GraphPad Prism or Statistica, that help us to get maximum of information.

Abstract

Aim of the work is to compare chosen biopolymers and critically evaluate their ability to provide of model drugs with different solubility. Chitosan and Alginate-natrium are natural derivates of cellulose that are sparingly used in many fields of industry like food or pharmacy. The physico-chemical properties (solubility, toxicity, temperature of glassy transition) of these substituted carbohydrates indicates the suitability of their use as a potential excipient of solid peroral dosage forms which otherwise represent matrix tablets.
      A release of well- and poor- soluble model drug from matrices containing biopolymers mentioned above with/without combination of synthetic polymer (Kollidon®) will be discussed. Next, the ability of matrices to provide extended release of the model drugs and the mechanism of their release will be compared depending on the composition of the tablets. Further, a visual observation of drug release will be shown to obtain more details about swelling and erosion.
     Matrix tablets containing synthetic and natural retardants were prepared by direct compression method (compression force 8 kN). The tablets were of cylindrical shape without facets of a diameter of 13 mm and weight of 0.5 ± 0.0010 g.
       All In vitro dissolution tests were performed according to the European Pharmacopoeia 9th edition using dissolution apparatus SOTAX AT7 Smart with paddles or baskets (37 ± 0.5 °C, 100 rpm). As a dissolution medium was used 900 mL of acidic buffer (pH 1.2). Amount of released drug was determined using UV/VIS spectroscopy. Dissolution profiles were evaluated by non-linear regression analysis.
Audience take away:
• The audience will get information about preparation of matrix tablets containing biopolymers and their ability to provide sustained release
• The results of the study may help researchers to decide which formulations are practically usable for extended drug release 
• Presented method of visualization during dissolution test also brings interesting results connected to process of the drug release from matrix tablet