Title : Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease.
A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood. In the setting of excessive central adiposity, insulin resistance is the major underlying cause of fat accumulation in hepatocytes. Because of the difficulties with human trials, several animal models have been developed for this purpose mainly characterized as follows: genetically disturbed or murine fatty liver, methionine-choline deficient diet fed or murine steatohepatitis, and high-fat or sucrose diet fed models. Although these animal models have provided useful information, none of them accurately reflect genetic, metabolic and biochemical characteristics of the human disease.
Metin Basaranoglu has completed Medical School and Internal Medicine residency at Istanbul University then, completed gastroenterology fellowship and postdoctoral studies in St. Louis University School of Medicine/Liver Centre, St. Louis/MO, USA. He is the author of a book “NASH pathogenesis (NY, 2009)” and a book chapter “Metabolic Aspects of Chronic Liver Diseases” published (NY, 2008). He has served on the editorial boards for the journals and referee for "Gastroenterology", "Hepatology", and "The American Journal of Gastroenterology". He is the member of The American Association for the Study of Liver Diseases (AASLD) and The European Association for the Study of the Liver (EASL). He was awarded twice by AASLD (1998/2002) and once by EASL (2009).
His main research areas : Inflammatory bowel disease (IBD), Crohn's, Ulcerative Colitis, fatty liver disease/NAFLD, Hepatology, echoendoscopy (EUS), advanced endoscopy and i-scan (pentax), RF ablation and fibroscan for liver.