Title : Biopolymer Grafting of Soy Lecithin Liposomes Via Poly(ethylene glycol) methyl ether-Cholesterol as A Novel Delivery System for Paclitaxel
The utilization of polymer-grafted liposomes for the delivery of anticancer drug, particularly Paclitaxel (PTX) to the tumor target sites is a new and advanced method in the branch of chemotherapy. Liposome in the pharmaceutical view is the possessor of superb properties for drug delivery, but it is held back by the fact that liposome has a very short circulation time. The grafting of methylated-polyethylene glycol on the surface of liposome is the key to solve and eliminate the only drawback for liposome as a drug delivery system. In this study, liposome formulated from natural soy lecithin (SLP) was prepared and partially surface modified with methoxy polyethylene glycol (mPEG) for the delivery of PTX. The PTX/SLP@mPEG was successfully developed with nanometric particle size, high entrapment efficiency, and long-lasting drug release. Moreover, in vitro cytotoxicity assays demonstrated that SLP@mPEG is nontoxic and cytocompatible. PTX/SLP@mPEG also showed remarkable suppress the proliferation of cancer cells. In addition, the in vivo antitumor effect of PTX/SLP@mPEG was also observed in a mouse model that had been subcutaneously inoculated with breast cancer cells by virtue of higher passive accumulation in tumor tissue via the enhanced permeability retention effect. Overall, these obtained results provide insights into the potential of SLP@mPEG as a platform for the development of more effective therapies against cancers.