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Teimuraz Lezhava

Title: Epigenetic alternation under the influence of peptide bioregulators of the aging heterochromatin

Teimuraz Lezhava

Tbilisi State University, Georgia

Biography

Updated Soon...

Abstract

In the  present investigation are considered eligible the  modification of heterochromatin (total heterochromatin, constitutive – pericentromeric and telomeric  heterochromatin, nucleolus organizer regions - NORs and facultative heterochromatin)  under the influence of peptide bioregulators (tetrapeptides Ala-Glu-Asp-Gly; Lys-Glu-Asp-Ala and  dipeptide Lys-Glu)  and heavy metals in lymphocytes cultured from individuals at the age of 80 and over.

The results showed:

1) progressive heterochromatinization of total, constitutive (pericentromeric, telomeric and NOR heterochromatin) and facultative heterochromatin occurred with aging; 2) peptide bioregulatorsinduce unrolling deheterochromatinization of total heterochromatin; 3)each peptide bioregulator  selectively effect definite the deheterochromatinization of chromosomes; 4) Co2+ ions in combination with the bioregulator  tetrapeptide (lys-Glu-Asp-Ala) has induction higher level of sister chromatid exchanges -  deheterochromatinization of the telomeric heterochromatin regions in lymphocytes of old individuals.

     The proposed genetic mechanism responsible for constitutive and  facultative heterochromatin remodeling (hetero- and deheterochromatinization pericentromeric and  telomeric region) of old age  may lead for the prolongation of the span of life and to the development of therapeutic treat of the aging pathologies