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To discuss scientific and commercial issues around regulation, manufacturing, partnering, trails in the field of pharma, join the leading experts at pharma conferences 2017.

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M. Teresa Carvajal

Leading speakers for pharma summits-M. Teresa Carvajal

Title: Impact of drug crystal habit on drug-carrier surface interactions and consequent powder dispersion from dry powder inhalers

M. Teresa Carvajal

Purdue University, USA

Biography

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Abstract

The physicochemical properties of drug particles from two polymorphs were studied in terms of their observable effects on the nature and strength of the interactive forces between drug particles from different polymorphs and lactose in dry powder mixes for inhalation. The type of systems was chosen to investigate the interactive properties of two different surfaces of the same chemical composition. The hypothesis was that the two polymorphs of the same drug would exhibit measurable differences in their inter-­‐ particle cohesive/adhesive interactions. These manifest themselves macroscopically by having different ease of metering and in powder dispersion, that in turn at the molecular level are the result of surface energetics of the two polymorphs. The results of the surface energy properties of the two polymorphs revealed that polymorph A elongated crystal habit exhibited stronger cohesive and adhesive interactions that its counterpart polymorph B rounded. In addition, the results also suggest that the effects of surface geometry of the drug particles continues to play a significant, although not necessarily dominant role in the aerosol dispersion and deposition properties of the powder mixes.