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Maha Mohamed Adel Nasra

Title: Silymarin loaded mesoporous silica nanoparticles: Preparation, optimization, pharmacodynamic and oral multi-dose safety assessment

Maha Mohamed Adel Nasra

Alexandria University,Egypt

Biography

•Maha Mohamed Adel Nasra ,Assistant professor of pharmaceutics  at faculty of pharmacy alexandria university
•Good experience in drug formulation development  , advanced and targeted drug delivery systems ,controlled drug delivery , nanotechnology
•My current assistant professor job involves teaching different classes  for undergraduate bachelors of pharmacy and clinical pharmacy students as well as teaching and supervising  M.PSc and Ph.D. students
•About 6 conference abstracts  and 6 published articles
 

Abstract

The present work aimed to prepare Silymarin loaded MCM-41 type mesoporous silica nanoparticles (MSNs) and assess the system’s solubility enhancement ability on the pharmacodynamic performance of Silymarin as a hepatoprotective agent. (MSNs) prepared by soft-templating technique, were loaded with Silymarin, characterized for particle size, zeta potential, surface properties, DSC and XRPD. DSC and specific surface area data confirmed deposition of Silymarin in an amorphous state in MSNs’ pores. In-vitro drug dissolution testing displayed enhanced dissolution rate of Silymarin upon loading on MSNs. High dose Acetaminophen was then used to inflict hepatic injury upon albino male Wistar rats simultaneously receiving either free Silymarin, Silymarin loaded MSNs or blank MSNs. plasma AST, ALT, albumin and total protein and liver homogenate content of TBARs or LDH as measures of antioxidant drug action were assessed for all animal groups. Results showed a significant superiority of Silymarin loaded MSNs to free drug in almost all parameters. Meanwhile prolonged administration of blank MSNs had no evident toxicity on rats.