Europe Pharma Conferences, The meeting place for pharma professionals from academia, industry, non-profit organization and government bodies to discuss the challenges and successes.

We are bringing together more than 100 elite speakers from Las Vegas, USA, dubai, new york, Chicago, Vancouver, India, UK, san Francisco, Florida, boston, Atlanta, san diego, orlando, Houston, Miami, dallas, san Antonio, phoenix, Edinburgh, Manchester, Birmingham, Melbourne, Brisbane, Canberra, cologne, Toronto, Australia, Germany, Canada, hong kong, florida, Las Vegas, Jordan, Turkey, Spain, UAE, Saudi Arabia, Egypt, Netherlands, France, Italy, Brazil, Israel, China, Japan to inspire and educate our attendees across the globe.

Highly recommended pharma conferences: pharma conferences, pharmaceutical conferences, pharmacy conferences, pharma conferences 2017, international pharmacy conference 2017, PDDS 2017, Pharmaceutics conferences 2017, Pharmaceutics conference 2017, pharma conferences Spain, pharma conferences Valencia, pharma conferences USA, pharma conferences Asia, Pharma conference Europe, pharmaceutical conferences, pharmaceutical conferences 2017

Make sure you are at the forefront of the pharma industry, we have content, networking and potential partners for you at pharma conferences 2017, June 29 - July 1, 2017 at Valencia Spain.

We are bringing together more than 100 elite speakers from Las Vegas, USA, dubai, new york, Chicago, Vancouver, India, UK, san Francisco, Florida, boston, Atlanta, san diego, orlando, Houston, Miami, dallas, san Antonio, phoenix, Edinburgh, Manchester, Birmingham, Melbourne, Brisbane, Canberra, cologne, Toronto, Australia, Germany, Canada, hong kong, florida, Las Vegas, Jordan, Turkey, Spain, UAE, Saudi Arabia, Egypt, Netherlands, France, Italy, Brazil, Israel, China, Japan to inspire and educate our attendees across the globe.

Highly recommended pharma conferences: pharma conferences, pharmaceutical conferences, pharmacy conferences, pharma conferences 2017, international pharmacy conference 2017, PDDS 2017, Pharmaceutics conferences 2017, Pharmaceutics conference 2017, pharma conferences Spain, pharma conferences Valencia, pharma conferences USA, pharma conferences Asia, Pharma conference Europe, pharmaceutical conferences, pharmaceutical conferences 2017

International pharma conferences 2017 will bring the experts from the whole value chain under one roof, which facilitate the plan for future manufacture, research and development.

We are bringing together more than 100 elite speakers from Las Vegas, USA, dubai, new york, Chicago, Vancouver, India, UK, san Francisco, Florida, boston, Atlanta, san diego, orlando, Houston, Miami, dallas, san Antonio, phoenix, Edinburgh, Manchester, Birmingham, Melbourne, Brisbane, Canberra, cologne, Toronto, Australia, Germany, Canada, hong kong, florida, Las Vegas, Jordan, Turkey, Spain, UAE, Saudi Arabia, Egypt, Netherlands, France, Italy, Brazil, Israel, China, Japan to inspire and educate our attendees across the globe.

Highly recommended pharma conferences: pharma conferences, pharmaceutical conferences, pharmacy conferences, pharma conferences 2017, international pharmacy conference 2017, PDDS 2017, Pharmaceutics conferences 2017, Pharmaceutics conference 2017, pharma conferences Spain, pharma conferences Valencia, pharma conferences USA, pharma conferences Asia, Pharma conference Europe, pharmaceutical conferences, pharmaceutical conferences 2017

Pharma conference, this event is dedicated to fostering partnerships and collaboration amongst the pharma professionals from the industry and academia and non-profit organization and government bodies. We are bringing together more than 100 elite speakers from Las Vegas, USA, dubai, new york, Chicago, Vancouver, India, UK, san Francisco, Florida, boston, Atlanta, san diego, orlando, Houston, Miami, dallas, san Antonio, phoenix, Edinburgh, Manchester, Birmingham, Melbourne, Brisbane, Canberra, cologne, Toronto, Australia, Germany, Canada, hong kong, florida, Las Vegas, Jordan, Turkey, Spain, UAE, Saudi Arabia, Egypt, Netherlands, France, Italy, Brazil, Israel, China, Japan to inspire and educate our attendees across the globe.

Highly recommended pharma conferences: pharma conferences, pharmaceutical conferences, pharmacy conferences, pharma conferences 2017, international pharmacy conference 2017, PDDS 2017, Pharmaceutics conferences 2017, Pharmaceutics conference 2017, pharma conferences Spain, pharma conferences Valencia, pharma conferences USA, pharma conferences Asia, Pharma conference Europe, pharmaceutical conferences, pharmaceutical conferences 2017

To discuss scientific and commercial issues around regulation, manufacturing, partnering, trails in the field of pharma, join the leading experts at pharma conferences 2017.

We are bringing together more than 100 elite speakers from Las Vegas, USA, dubai, new york, Chicago, Vancouver, India, UK, san Francisco, Florida, boston, Atlanta, san diego, orlando, Houston, Miami, dallas, san Antonio, phoenix, Edinburgh, Manchester, Birmingham, Melbourne, Brisbane, Canberra, cologne, Toronto, Australia, Germany, Canada, hong kong, florida, Las Vegas, Jordan, Turkey, Spain, UAE, Saudi Arabia, Egypt, Netherlands, France, Italy, Brazil, Israel, China, Japan to inspire and educate our attendees across the globe.

Highly recommended pharma conferences: pharma conferences, pharmaceutical conferences, pharmacy conferences, pharma conferences 2017, international pharmacy conference 2017, PDDS 2017, Pharmaceutics conferences 2017, Pharmaceutics conference 2017, pharma conferences Spain, pharma conferences Valencia, pharma conferences USA, pharma conferences Asia, Pharma conference Europe, pharmaceutical conferences, pharmaceutical conferences 2017

 

Konstantin Ostrovskiy

Title: Development of intravenous form of rifapentine and its in vivo evaluation

Konstantin Ostrovskiy

Drugs Technology LLC, Russia

Biography

•2011 graduate from D.I. Mendeleev Russian University of Chemical Technology, as an engineer (department of organic chemical technology, chair of pharmaceutical and cosmetic products)
•2011-2015 employment in Nanosystem Ltd. (Russia, Moscow) as a Junior Research Associate
•2014-present day collaboration with G.F. Gause Institute of New Antibiotics
•2015-present day employment in Drugs Technology LLC as a Junior Research Associate
•working at PhD dissertation at present
•1 scientific publication in June, 2016; 2 more publications in press
 

Abstract

Rifapentine is a semisynthetic rifamycin antibiotic highly active against a broad spectrum of microorganisms including Mycobacterium tuberculosis. Rifapentine solubility in water is very low (0.1 mg/ml); therefore, its dosage forms are currently limited to tablets or capsules (e.g. Priftin®). At the same time, development of water-compatible injectable formulations would extend its clinical potential. Therefore, the objective of the present study was to investigate the applicability of proteins: human serum albumin, succinylated gelatin, and sodium caseinate − for solubilization of rifapentine and evaluate the efficacy and safety of the novel injectable formulations.

The formulations were obtained by precipitation or homogenization yielding freeze-dryable suspensions. Upon reconstitution and proper dilution the lyophilizates formed stable colloidal solutions with the particle size of 10-15 nm suitable for i.v. administration. The best results were obtained with albumin (RFP-HSA) and casein that enabled total concentrations of rifapentine in the aqueous phase of up to 10 mg/ml, which was ~100-fold higher than the solubility of the pure substance.
The antituberculosis effect of RFP-HSA evaluated in Balb/C mice infected with M. tuberculosis (H37Rv, ~106 CFU per animal) was similar to that of the oral substance in the lower treatment doses (5 and 10 mg/kg) and appeared to be superior in the highest dose (20 mg/kg).

Based on the moderate LD50 value (340 mg/kg) in BDF mice, the RFP-HSA formulation could be classified as low toxic. In the chronic toxicity study (outbred rats) RFP-HSA administered i.v. and RFP substance given per os exhibited similar adverse effects. However, in contrast to conventional oral formulations, the intravenous formulation of rifapentine did not induce any signs of gastrointestinal toxicity and cardiotoxicity, thus suggesting its usefulness for clinical application.

In conclusion, solubilization with proteins appeared to be a promising approach for development of the effective and safe injectable formulations of rifapentine.

Audience will learn:
•The possibility to obtain a new form of antibiotic which proved to be safe and effective, is a reason for further research in this field and manufacture of a novel pharmaceutical.
•Water-compatible form of rifapentine is an example how to make poorly soluble substances more soluble and stable in the aqueous media, without use of toxic and synthetic excipients. This technology is practically universal and can find broad application in other fields.