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Carlos Horacio Laino

Potential speakers for pharma events-Carlos Horacio Laino

Title: Pharmaceutical innovation in the treatment of pain: Combination of morphine with omega-3 fatty acids

Carlos Horacio Laino

National University of La Rioja, Argentina

Biography

Dr Laino obtained a PhD in Pharmacology with honors from University of Buenos Aires, Argentina. His main research is focused on the design, development and discovery of a new drug, a new combination of standard treatments, or new doses of current therapies. He is Director of the Biotechnology Institute and associate professor of the Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biochemistry of the National University of La Rioja, Argentina. The Biotechnology Institute applies animal models for drug discovery research in the field of pain, inflammation, depression and anxiety.

Abstract

Chronic pain affects the personal and social life of the patient, and often also their families. In some cases, after an acute pain the patient continues with chronic pain, which can be a result of diseases such as cancer.

Morphine is recommended as the first choice opioid in the treatment of moderate to severe acute and chronic pain. However, the development of adverse effects and tolerance to the analgesic effects of morphine often leads to treatment discontinuation.

This project describes a technological development with an innovative character, both in its pharmaceutical composition (morphine and omega-3 fatty acids) and in the pharmacological treatment associated with its use. Also, explores the preclinical evidence concerning the analgesic effects of omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid).

The main advantage of the new pharmaceutical composition and pharmacological treatment lies in the control of pain with a sub-therapeutic dose of morphine which would eliminate or potentially decrease its adverse effects. 

Other important clinical benefits of using it in terminally ill patients, (such as cancer sufferers) or patients with other types of chronic diseases are the decrease in tolerance to analgesic effect and the reduction in body weight loss and constipation.