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Mihir K. Raval

Title: Co-crystallization as an effective particle engineering technique for functionality improvement of APIs

Mihir K. Raval

Saurashtra University, India

Biography

Dr. Mihir Raval is a Head of Department of Pharmaceutical Sciences of Saurashtra University (Accredited Grade “A” by NAAC) at Rajkot, in the state of Gujarat (India). Apart from Pharmacy, he is heading Department of Biochemistry of the same university. Dr. Mihir Raval is a Dean of Pharmacy Faculty and a Senate member of the University. He is also serving as Director of Industry Institute Interaction Cell (IIIC) of the Saurashtra University. He has served as a resource person in many national – international level conferences. He has more than 40 publications in various reputed National and International journals to his credit. He has also worked as Production scientist in Pharma industry. 

Abstract

Majority of APIs in existence and in the drug discovery process belong to poorly water soluble class. Poor physicochemical properties of API results in to poor bioavailability. Now a day industry is fighting with the bioavailability issues of APIs. 

Not only the physicochemical properties but also the mechanical properties of API should be in favor to achieve the successful formulation. Flow and compactibility of particles or powder are the most important consideration in the solid dosage manufacture. 
Majority of research works are based on the improvement of bioavailability of API using various approach. Very few or none of the works have been done to improve physicochemical as well as mechanical properties simultaneously.

Cocrystallization is a particle engineering technique which can be used to modify and improve both the properties simultaneously. Pharmaceutical industries are more interested in the process of manufacturing the dosage forms with minimum steps, less time consuming and of course less laborious way. Cocrystallization technique can lead to the better formulation as an oral drug delivery with fast processing.