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Renata Pasqualini

Speaker for drug conferences-Renata Pasqualini

Title: Ligand-directed targeting and molecular imaging based on vascular zip codes revealed by in vivo phage display

Renata Pasqualini

University of New Mexico Health Science Center, USA

Biography

Dr. Pasqualini is the Budke Professor of Medicine and Cancer Experimental Therapeutics, Associate Director for Translational Research, and Chief of the Division of Molecular Medicine at the University of New Mexico Cancer Center. She received a Ph.D. from the Ludwig Institute for Cancer Research, and did postdoctoral training at Harvard Medical School and at the Burnham Institute in La Jolla, CA. In addition to her activities as the principal investigator and head of a large research laboratory first at the University of Texas M. D. Anderson Cancer Center, and now at the University of New Mexico Health Sciences Center, she serves as a board member, reviewer, and chair in multiple review panels for the National Institutes of Health, the Department of Defense, the Department of Energy, along with several other American, Asian, and European Foundations that support basic and clinical research. She is a Referee for several top journals featuring cutting edge research and technology and has published over 200 papers.

Abstract

We have developed in vivo phage display, a functional peptide and antibody screening established in animal models and later in patients. Isolation of homing ligands enables subsequent identification of tissue-specific receptors. Systematic implementation of this strategy advanced the construction of a comprehensive map of vascular markers in each organ, tissue, or disease. Indeed, our pioneering discoveries of tissue-specific and angiogenesis-related receptors (vascular "ZIP codes") may lead to a new ligand-directed pharmacology. Within the past few years, the characterization of the vascular diversity associated with individual cancer patients using antibody-based drug discovery in a precision medicine context, and optimization of targeted nanoparticles for drug delivery without off-target toxicity represent fertile ground for discovery and drug development.