Kariane Mendes Nunes is currently Adjunct Professor at the Federal University of the Western of Pará (UFOPA), in Amazon Region - Brazil,.She has PHD in Pharmaceutical Sciences at the University of São Paulo (2012) and held Post-doctorate studies at the Federal University of Para (2013). She has experience in Pharmaceutical Sciences area with emphasis in pharmaceutical technology, acting on the following themes: innovation and development of liquid crystalline and mucoadhesive drug delivery systems. In addition, she has investigated the applicability of natural compounds from the Brazilian Amazon Region as new raw material for the development of the crystal liquid and phytocosmetics.
The technology of drug delivery systems is relatively recent, the first drug delivery devices emerged in the last century. Since then, numerous controlled release drug systems were designed to overcome the therapeutic limitations regarding the use of the traditional pharmaceutical formulations. To address these concerns, during my presentation, I will discuss about the trends and issues in the technological scope of the development of in situ gelling liquid crystalline systems based on amphiphilic lipids for mucosal drug delivery. In this context, I will present my research developed at the University of São Paulo, during my PhD, of a fluid precursor system (FPS) based on a mixture of monoglycerides (MO), Cremophor® (CREM) and water. This formulation exhibits in situ gelation to a liquid crystalline phase (LCP). To study the applicability of these systems for mucosal controlled drug delivery via a syringe, We evaluated the effects of the MO/CREM ratio (w/w) and the water content [WC (% w/w)] on the self-assembly profile, rheological properties, syringeability, hydration, and mucoadhesion using a systematically investigation with a full factorial design. Therefore, for the experimental design we applied the following methods: Polarized light microscopy (PLM), Small-Angle X-ray Scattering (SAXS), Rheological measurements, Syringeability tests, Hydration studies and In vitro assessment of mucoadhesion. The data arising from this research were extremely useful for effective drug delivery systems (DDS) engineering and its end usage properties, which enabled the first unpublished results about the in vitro drug release performance from the in situ gelling liquid crystalline systems based on monoglycerides (MO)). Furthermore, a new research will be presented on the applicability of Murumuru butter (Astrocaryummurumuru Mart.) from the Brazilian Amazon region as new raw material for the development of the liquid crystalline systems.
Audience will learn:
a) The audience can learn the steps necessary for the design of In Situ-Gelling Liquid Crystalline Phase drug delivery systems with application into confined spaces, such as,the vaginal cavities and periodontal pocket.
b) Understand the anatomical and physiological limitations that should be considered during the development of drug delivery systems (DDS) with application in confined spaces, including the limited size and depth of the area and the flow of the relevant bodily fluid, which can promote a rapid erosion of the traditional pharmaceutical formulations.
c) Advantages of In Situ-Gelling Liquid Crystalline Phase drug delivery systems:
• Fluidity, enabling the application into the desired site through a syringe;
• Suitable mucoadhesion, to persist for an adequatetime at the site;
• Ability to self-assemble intoa viscous liquid crystalline phase (LCP) in the presence of excess ofwater, which can control the speed and extension of the drug release;
• Can be carrying within their compartments drugs of different polarities and molecular weight.
d) Applicability of amphiphilic lipids to obtain crystalline liquid delivery systems:
• Synthetic compounds: Monoglycerides (MO) and;
• Natural compounds: Butters, vegetable and essential oils from the Brazilian Amazon Region.